1. the data demonstrate a critical role for endosialin-expressing primary tumor pericytes in mediating metastatic dissemination and identify endosialin as a promising therapeutic target in breast cancer PMID: 27635044
2. Our data show that deletion of CD248 reduces susceptibility to liver fibrosis via an effect on PDGF signaling. PMID: 26078290
3. Endosialin is a potential regulator of phenotypic remodeling of vascular smooth muscle cells contributing to atherosclerosis. PMID: 28126825
4. suggest that CD248 stromal cells have a pathogenic role in renal fibrosis PMID: 26633297
5. We conclude that CD248 is required for PDGFRbeta-dependant capillary sprouting but not splitting angiogenesis, and identify a new role for CD248 expressed on pericytes in the early stages of physiological angiogenesis during muscle remodelling. PMID: 25243742
6. Tem1-TT vaccination elicited CD8+ and/or CD4+ T cell responses against immunodominant TEM1 protein sequences. Prophylactic immunization of animals with Tem1-TT prevented or delayed tumor formation in several tumor models. PMID: 24642465
7. Expression of CD248 was seen in osteoblasts, but not osteoclasts. CD248(-/-) mouse tibiae had higher bone mass and superior mechanical properties compared to WT mice. Primary osteoblasts from CD248(-/-) mice induced increased bone mineralization PMID: 22674221
8. The multiple pathways regulated by the cytoplasmic domain of CD248 highlight its potential as a therapeutic target to treat cancer. PMID: 21549007
9. our observations suggest that Tem1 is expressed throughout embryonic and adult development in several types of mesenchymal cells closely related to blood vessels. PMID: 21402174
10. required for efficient lymph node expansion PMID: 20432232
11. Tem1 have significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process PMID: 16492758
12. In the embryo when analysed by confocal microscopy endosialin on vessels does not colocalise with endothelial cells expressing CD31, rather, endosialin is restricted to closely associated perivascular cells that also express the pericyte marker NG2. PMID: 16965941
13. CD248 expression helps define a subset of lymphoid tissue stromal cells which play a role in remodelling during tissue development, infection and repair PMID: 17628549

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KEGG: mmu:70445

STRING: 10090.ENSMUSP00000070847

UniGene: Mm.29597