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中文名稱：小鼠8羥基脫氧鳥苷(8-OHdG)酶聯免疫試劑盒
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貨號：CSB-E10527m
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規格：96T/48T
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價格：￥3800/￥2500
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其他：
產品詳情
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產品描述：小鼠8羥基脫氧鳥苷(8-OHdG)酶聯免疫試劑盒（CSB-E10527m）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的8-OHdG含量。8-OHdG 是 DNA 氧化損傷的生物標志物。其背景在于機體受內外界因素影響產生氧化應激，導致 DNA 中鳥嘌呤氧化形成 8-OHdG。研究機制多圍繞檢測其含量來評估氧化應激水平、DNA 損傷程度，及與腫瘤、神經退行性疾病等的關聯。試劑盒檢測范圍為0.78 pg/mL-50 pg/mL，適用于神經退行性疾病模型、衰老機制研究、環境毒理學評估及代謝性疾病等科研領域，可為氧化損傷相關機制研究、藥物篩選及抗氧化劑功效評價提供數據支持，廣泛應用于基礎醫學、藥理學及生物化學等科研場景。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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縮寫：8-OHdG
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種屬：Mus musculus (Mouse)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：0.78 pg/mL-50 pg/mL
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靈敏度：0.195 pg/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Cell Biology
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測定原理：quantitative
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測定方法：Competitive
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of mouse 8-OHdG in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:100 Average % 90 Range % 87-97 1:200 Average % 97 Range % 93-104 1:400 Average % 85 Range % 82-91 1:800 Average % 90 Range % 85-97 -
回收率：
The recovery of mouse 8-OHdG spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 89 85-93 EDTA plasma (n=4) 92 88-94 -
標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
pg/ml OD1 OD2 Average 50 0.071 0.074 0.073 25 0.120 0.130 0.125 12.5 0.200 0.206 0.203 6.25 0.335 0.340 0.338 3.12 0.573 0.554 0.564 1.56 0.858 0.841 0.850 0.78 1.129 1.139 1.134 0 2.215 2.185 2.200 -
數據處理：
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貨期：3-5 working days
引用文獻
- Gui-zhi-fu-ling-wan alleviates bleomycin-induced pulmonary fibrosis through inhibiting epithelial-mesenchymal transition and ferroptosis ZY Chen, MM Ma, R Wang, QQ Zhang,Frontiers in Pharmacology,2025
- Afamin Ameliorates Testosterone Propionate (TP)-Induced Oxidative Stress and Mitochondrial Damage in Human Ovarian Granulosa Tumor Cells (KGN) by Upregulating the Expression of SIRT1 YL Ma, ZW Li, Z Wang, AJ Yang,Molecular Biology,2024
- Fisetin exerts neuroprotective effects in vivo and in vitro by inhibiting ferroptosis and oxidative stress after traumatic brain injury H Yang, Y Hong, M Gong, S Cai, Z Yuan,Frontiers in Pharmacology,2024
- Myricanol prevents aging‐related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5 S Shen,MedComm,2024
- Temporal analysis of lung injury induced by real‐ambient PM2.5 exposure in mice H Zeng,Environmental toxicology,2023
- Alleviation of ischemia-reperfusion induced renal injury by chemically modified SOD2 mRNA delivered via lipid nanoparticles Y Hou,Molecular therapy. Nucleic acids,2023
- Panax notoginseng saponins prevent dementia and oxidative stress in brains of SAMP8 mice by enhancing mitophagy Y Yang,BMC complementary medicine and therapies,2024
- Apigenin alleviates cancer drug Sorafenib induced multiple toxic effects in Swiss albino mice via anti-oxidative stress Deepti Singh,Toxicology and Applied Pharmacology,2023
- Controlled Release of Hydrogen‐Carrying Perfluorocarbons for Ischemia Myocardium‐Targeting 19F MRI‐Guided Reperfusion Injury Therapy C Nie,Advanced Science,2023
- Neuroinflammation, Oxidative Stress, Apoptosis, Microgliosis and Astrogliosis in the Cerebellum of Mice Chronically Exposed to Waterpipe Smoke N Hamadi,Biomedicines,2023
- Implication of Lupeol in compensating Sorafenib-induced perturbations of redox homeostasis: A preclinical study in mouse model H Fatma,Life sciences,2023
- Rosiglitazone reduces diabetes angiopathy by inhibiting mitochondrial dysfunction dependent on regulating HSP22 expression L Yu,iScience,2023
- Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia P García-Rodríguez,Nutrients,2022
- Circular RNA circ_Cabin1 promotes DNA damage in multiple mouse organs via inhibition of non-homologous end-joining repair upon PM2. 5 exposure H Zeng,Archives of toxicology,2021
- The mechanism of CaMK2α-MCU-mitochondrial oxidative stress in bupivacaine-induced neurotoxicity Z Liu,Free Radical Biology and Medicine,2020
- Rosmarinic Acid, the Main Effective Constituent of Orthosiphon stamineus, Inhibits Intestinal Epithelial Apoptosis Via Regulation of the Nrf2 Pathway in Mice Cai X, et al,Molecules,2019
- Renoprotective effects of brown adipose tissue activation in diabetic mice Cai YY,Journal of Diabetes,2019
- HSP22 suppresses diabetes-induced endothelial injury by inhibiting mitochondrial reactive oxygen species formation LingligYu, et al,Redox Biology,2019
- Lentivirus-Mediated HDAC3 Inhibition Attenuates Oxidative Stress in APPswe/PS1dE9 Mice Yu L.et al,J Alzheimers Dis,2018
- RA-XII exerts anti-oxidant and anti-inflammatory activities on lipopolysaccharide-induced acute renal injury by suppressing NF-魏B and MAPKs regulated by HO-1/Nrf2 An X.et al,Biochem Biophys Res Commun,2017
- Klotho ameliorates cyclosporine A?induced nephropathy via PDLIM2/NF-kB p65 signaling pathway Meihua Jin.et al,Biochemical and Biophysical Research Communications,2017
- Effects of methyl mercury on the activity and gene expression of mouse Langerhans islets and glucose metabolism. Maqbool F.et al,Food Chem Toxicol.,2016
- The Protective Effects of Melatonin Against Oxidative Stress and Inflammation Induced by Acute Cadmium Exposure in Mice Testis Li R. et al,Biol Trace Elem Res,2015
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