1. The expression of HOXB13, IL17BR, and mammaglobin 1 in sentinel lymph nodes predict the outcome of primary breast cancer patients. PMID: 29729704
2. The results indicate that the IL-17B/IL-17RB signaling can promote the growth and migration of tumor cells. PMID: 27146881
3. IL-17RB can enhance thyroid cancer cell invasion and metastasis via ERK1/2 pathway-mediated MMP-9 expression, suggesting that IL-17RB may act as a potential therapeutic target for thyroid cancer therapy. PMID: 28715683
4. IL-4 signaling up-regulates the IL-25 axis in human monocytic cells, and IL-25 may provide autocrine signals in monocytes and macrophages to sustain IL-17Rb expression and predispose to alternative activation. PMID: 28421819
5. Our results identify a biochemical role for WDTC1 and extend the functional range of the CRL4 complex to the suppression of fat accumulation. PMID: 27113764
6. Atopic IL-17RB(+) DCs can be up-regulated by LPS and promote a TH2-type response, implying that the IL-25/IL-17RB pathway may represent a potential molecular mechanism underlying the regulation of ECs on DCs in allergic airway disease. PMID: 28132739
7. IL-17RB(+) granulocytes and T2M cells from peripheral blood were increased in subjects with asthma, and the 2 cell types correlated with degree of airflow obstruction. PMID: 27979026
8. collectively, this study uncovers a new role for CRL4CDT2 in protecting genomic integrity against replication stress via regulated proteolysis of PCNA-associated SDE2 and provides insights into how an integrated UBL domain within linear polypeptide sequence controls protein stability and function. PMID: 27906959
9. This comprehensive review details the recognition of activity, signaling, and the roles of IL17B-IL17RB in breast cancer have caused to determination of new therapeutic mechanisms--{REVIEW} PMID: 28160754
10. The Breast Cancer Index (BCI) is a continuous risk index model of two previously described biomarkers: molecular grade index (MGI) and HOXB13:IL17BR (H:I) ratio PMID: 26728744
11. Therefore, IL-17E/IL-17RB signaling represents a potential therapeutic target for treatment of hepatocellular carcinoma PMID: 27000993
12. GS is acetylated at lysines 11 and 14, yielding a degron that is necessary and sufficient for binding and ubiquitylation by CRL4(CRBN) and degradation by the proteasome. PMID: 26990986
13. Studies indicate that interleukin 17 (IL-17B)/interleukin 17 receptor B (IL-17RB) signaling is essential for pancreatic cancer malignancy. PMID: 26285835
14. IL-17RB has an essential role in pancreatic cancer growth, invasion, and metastasis. PMID: 25732306
15. High IL17RB expression is associated with breast cancer. PMID: 23497539
16. Results show that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promot tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells. PMID: 23851503
17. The increased IL-25 levels in plasma and the expression of IL-17RA and IL-17RB on eosinophils in allergic asthma patients suggests that IL-25 may activate eosinophils during allergic inflammation. PMID: 24247484
18. Allergen provocation induces functionally relevant, increased expression of IL-25 and its receptor in the asthmatic bronchial mucosa and dermis of sensitized atopic subjects. PMID: 21570719
19. In summary we established a new mechanism of IL17RB regulation-Smurf2 dependent degradation of its adaptor protein DAZAP2. PMID: 22070932
20. The present study identified upregulation of IL17RB during natural allergen exposure in patients with seasonal allergic rhinitis (SAR). PMID: 21252617
21. Results indicate that IL17RB may be the only gene expressed in CD4+ T cells whose transcript measurement is correlated with the variation in IgE level in asthmatics, but correlation between IL17RB and IgE was restricted to males only. PMID: 21473777
22. Increased expression of IL-17RB on allergen-challenged basophil is regulated by IL-3, inhibits apoptosis and promotes IgE-mediated degranulation of basophils PMID: 20545698
23. The IL17RB protein expression increases during disease progression of breast cancer to hormonal therapy. PMID: 16609001
24. HOXB13 and IL17BR has a role in progression of early-stage breast cancer PMID: 17008703
25. HOXB13 and IL17BR have roles in breast cancer PMID: 17453342
26. An index composed of inherited (CYP2D6) and tumor (HOXB13/IL17BR) gene variation identifies patients with varying degrees of resistance to tamoxifen. PMID: 18794098
27. Our results revealed that the IL-17RB +5661 G>A locus has a dominant and protective genetic effect on the development of asthma. PMID: 19118269

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HGNC: 18015

OMIM: 605458

KEGG: hsa:55540

STRING: 9606.ENSP00000288167

UniGene: Hs.654970