Human Cystatin-SN(CST1) ELISA kit
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中文名稱(chēng)：人胱抑素SN(CST1)酶聯(lián)免疫試劑盒
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貨號(hào)：CSB-EL006088HU
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規(guī)格：96T/48T
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價(jià)格：￥3600/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：人胱抑素SN(CST1)酶聯(lián)免疫試劑盒（CSB-EL006088HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織培養(yǎng)上清液,尿液、組織勻漿、細(xì)胞裂解物樣本中的CST1含量。CST1（胱抑素C）是一種分泌蛋白，屬于胱抑素家族，具有抑制組織蛋白酶活性的功能。在腫瘤生長(zhǎng)、血管生成、浸潤(rùn)和轉(zhuǎn)移中起重要作用。通過(guò)生物信息學(xué)分析，研究人員揭示了CST1在乳腺癌等癌癥中的潛在作用機(jī)制，為癌癥診斷和治療提供了新的靶點(diǎn)。試劑盒檢測(cè)范圍為0.156 ng/mL-10 ng/mL，科研領(lǐng)域可用于探究CST1在黏膜防御機(jī)制、炎癥相關(guān)信號(hào)通路或腫瘤微環(huán)境中的生物學(xué)功能，也可作為研究慢性炎癥性疾病、黏膜屏障功能障礙或腫瘤標(biāo)志物篩選的工具，為疾病機(jī)制研究提供數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
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別名：CST1 ELISA Kit; Cystain SAI ELISA Kit; Cystain-SA-I ELISA Kit; Cystatin 1 ELISA Kit; Cystatin-1 ELISA Kit; Cystatin-SN ELISA Kit; Cystatin1 ELISA Kit; Cysteine proteinase inhibitor, type 2 family ELISA Kit; CYTN ELISA Kit; CYTN_HUMAN ELISA Kit; Salivary cystatin SA1 ELISA Kit; Salivary cystatin-SA-1 ELISA Kit
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縮寫(xiě)：CST1
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Uniprot No.：
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種屬：Homo sapiens (Human)
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樣本類(lèi)型：serum, plasma, cell culture supernates,urine, tissue homogenates, cell lysates
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檢測(cè)范圍：0.156 ng/mL-10 ng/mL
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靈敏度：0.039 ng/mL
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反應(yīng)時(shí)間：1-5h
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樣本體積：50-100ul
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檢測(cè)波長(zhǎng)：450 nm
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研究領(lǐng)域：Cell Biology
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測(cè)定原理：quantitative
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測(cè)定方法：Sandwich
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精密度：
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線性度：
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回收率：
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標(biāo)準(zhǔn)曲線：
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數(shù)據(jù)處理：
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貨期：3-5 working days
引用文獻(xiàn)
- Cystatin C and cystatin SN as possible soluble tumor markers in malignant uveal melanoma MA Dikovskaya,Radiology and oncology,2023
- The Cystatin C and cystatin SN as possible soluble tumor markers in malignant uveal melanoma T Korolenko,Radiology and oncology,2023
- Epithelial CST1 Promotes Airway Eosinophilic Inflammation in Asthma via the AKT Signaling Pathway X Lisha,e-aair,2023
- Endogenous inhibitors of cysteine proteases cystatin C and cystatin SN in biological fluids of patients with intraocular melanoma as possible biomarkers and therapy targets Dikovskaya M.et al,EJC Supplements,2015
- P43: Endogenous inhibitors of cysteine proteases cystatin C and cystatin SN in biological fluids of patients with intraocular melanoma as possible biomarkers and ? M. Dikovskaya. et al,European Journal of Cancer Supplements,2015
- Identification of cystatin SN as a novel biomarker for pancreatic cancer. Jiang J.et al,Tumour Biol.,2015
- Salivary Composition Is Associated with Liking and Usual Nutrient Intake Méjean C. et al,PLoS One,2015
- Multi-omics profiling reveals that eating difficulties developed consecutively to artificial nutrition in the neonatal period are associated to specific saliva composition Morzel M. et al,J Proteomics,2015
- Caffeine increases the expression of cystatin SN in human submandibular acinar-like HSG cells Dsamou M et al,Arch Oral Biol,2013
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靶點(diǎn)詳情
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功能：Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.
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基因功能參考文獻(xiàn)：
- Results revealed that CST1 expression was upregulated in colon cancer (CC) compared with normal tissues and contributed to CC cell proliferation. PMID: 29845224
- High CST1 expression is negatively correlated with survival of breast cancer patients. CST1 promotes cell proliferation, clone formation, and metastasis in breast cancer cells. CST1 is a novel potential prognostic biomarker and therapeutic target for breast cancer. PMID: 28523467
- this results identified cystatin 1 as a biomarker in patients with seasonal allergic rhinitis PMID: 28633877
- These results indicate that CST1-mediated extracellular CatB activity enhances tumor development by preventing cellular senescence. PMID: 28383558
- interactions of human family 1 & 2 cystatins with cathepsin L1 PMID: 27764212
- high expression of Cystatin SN is a significant prognostic indicator of a higher rate of recurrence, metastatic risk, and poor survival in patients with surgically resected NSCLCs. PMID: 25648368
- In conclusion, our data suggest that CST1 might contribute to the proliferation of pancreatic cancer cells and could be a potential biomarker for the early detection of pancreatic cancer. PMID: 25577248
- CST1 may contribute to inactivation of protease allergens and help re-establish homeostasis of the nasal membranes. PMID: 23950865
- CST1 expression at both the messenger RNA and protein levels was barely detected in control cells, which included early passage proliferating, quiescent, or immortal human fibroblasts PMID: 21636832
- Murine monoclonal antibodies were made which can distinguish between CST1 and CST2. PMID: 15829315
- CST1 might be highly involved in gastric tumorigenesis and regulate the proteolytic activity of cysteine proteases. PMID: 19463800
- Identification of Cystatin SN as a novel tumor marker for colorectal cancer. PMID: 19513549
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亞細(xì)胞定位：Secreted.
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蛋白家族：Cystatin family
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組織特異性：Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid.
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