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中文名稱：人補體C1q腫瘤壞死因子相關(guān)蛋白6(C1QTNF6)酶聯(lián)免疫試劑盒
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貨號：CSB-EL003651HU
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規(guī)格：96T/48T
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價格：￥3600/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：人補體C1q腫瘤壞死因子相關(guān)蛋白6(C1QTNF6)酶聯(lián)免疫試劑盒（CSB-EL003651HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的C1QTNF6含量。C1QTNF6是一種與炎癥和腫瘤相關(guān)的蛋白，其高表達與多種癌癥的預(yù)后不良相關(guān)。研究顯示，C1QTNF6可能通過影響細胞遷移和侵襲能力來促進腫瘤發(fā)展，其具體機制涉及細胞周期、G2M檢測點、上皮-間質(zhì)轉(zhuǎn)化和血管生成信號通路。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，科研人員可將其應(yīng)用于代謝性疾病機制研究、慢性炎癥相關(guān)信號通路探索，或腫瘤微環(huán)境中細胞因子調(diào)控等領(lǐng)域，為揭示C1QTNF6在疾病發(fā)生發(fā)展中的功能提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名：C1q and tumor necrosis factor related protein 6 ELISA Kit; C1QT6_HUMAN ELISA Kit; C1qtnf6 ELISA Kit; Complement C1q tumor necrosis factor related protein 6 ELISA Kit; Complement C1q tumor necrosis factor-related protein 6 ELISA Kit; CTRP 6 ELISA Kit; CTRP6 ELISA Kit; OTTHUMP00000197772 ELISA Kit; OTTHUMP00000197774 ELISA Kit; PRO1151 ELISA Kit; UNQ581 ELISA Kit; ZACRP6 ELISA Kit
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縮寫：C1QTNF6
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Uniprot No.：
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種屬：Homo sapiens (Human)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：0.312 ng/mL-20 ng/mL
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靈敏度：0.078 ng/mL
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反應(yīng)時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領(lǐng)域：Others
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of human C1QTNF6 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 97 Range % 92-101 1:2 Average % 105 Range % 99-108 1:4 Average % 90 Range % 84-94 1:8 Average % 87 Range % 82-91 -
回收率：
The recovery of human C1QTNF6 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 92 85-96 EDTA plasma (n=4) 90 82-93 -
標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
ng/ml OD1 OD2 Average Corrected 20 2.778 2.662 2.720 2.600 10 1.926 1.905 1.916 1.796 5 1.315 1.342 1.329 1.209 2.5 0.703 0.734 0.719 0.599 1.25 0.390 0.381 0.386 0.266 0.625 0.295 0.288 0.292 0.172 0.312 0.203 0.209 0.206 0.086 0 0.119 0.121 0.120 -
數(shù)據(jù)處理：
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貨期：3-5 working days
引用文獻
- Role of C1q/TNF-Related Protein 6 for the Evaluation of Coronary Heart Disease Associated with Type 2 Diabetes M Li,Therapeutics and clinical risk management,2024
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靶點詳情
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基因功能參考文獻：
- The results establish CTRP6 as a novel metabolic/immune regulator linking obesity to adipose tissue inflammation and insulin resistance. PMID: 28726640
- We found both the rs229527 allele within C1QTNF6 (odds ratio [OR] = 1.23, confidence interval [95% CI]: 1.12-1.33, pAllelic = 4.60 . 10-6) and the rs2284038 allele within RAC2 (OR = 1.10, 95% CI: 1.01-0.19, pAllelic = 3.00 . 10-2) showed significant associations with Graves' Disease susceptibility. PMID: 28665696
- CTRP6 expression was decreased in scar tissues and TGF-beta1-treated dermal fibroblasts. CTRP6 inhibits TGF-beta1-induced the proliferation of dermal fibroblasts. PMID: 27155158
- CTRP6 inhibits the proliferation and migration of ovarian cancer cells via blocking IL-8/VEGF pathway. PMID: 26648301
- CTRP6 is expressed in human synoviocytes, and CTRP6 levels are increased in RA patients. PMID: 26404464
- C1qTNF6 is overexpressed and possibly contributes to tumor angiogenesis by activating the Akt pathway in many hepatocellular carcinomas. PMID: 21508531
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亞細胞定位：Secreted.
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