Human ADAMTS-like protein 2(ADAMTSL2) ELISA kit
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中文名稱：人ADAMTS樣蛋白2(ADAMTSL2)酶聯(lián)免疫試劑盒
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貨號：CSB-EL001318HU
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規(guī)格：96T/48T
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價格：￥3600/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：人ADAMTS樣蛋白2(ADAMTSL2)酶聯(lián)免疫試劑盒（CSB-EL001318HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的ADAMTSL2含量。ADAMTSL2是一種位于9q34.2的基因，其編碼的蛋白質(zhì)屬于ADAMTS（去整合素和金屬蛋白酶與血小板反應(yīng)蛋白基序）家族。該基因在多種生物中保守，其突變與地球物理發(fā)育不良有關(guān)。研究顯示，ADAMTSL2與LTBP4的異常相互作用可能與青少年特發(fā)性脊柱側(cè)凸有關(guān)，同時，ADAMTSL2蛋白和可溶性生物標(biāo)記物在識別非酒精性脂肪性肝病（NAFLD）的高危非酒精性脂肪性肝炎和纖維化中具有重要作用。試劑盒檢測范圍為3.12 ng/mL-200 ng/mL，適用于基礎(chǔ)科研中探索ADAMTSL2在發(fā)育調(diào)控、組織纖維化或代謝性疾病模型中的表達(dá)特征。為研究ADAMTSL2在疾病相關(guān)信號通路中的作用機(jī)制提供可靠工具，特別適用于生物標(biāo)志物篩選、基因功能驗證及病理機(jī)制研究等科研場景。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名：ADAMTS like 2 ELISA Kit; ADAMTS like protein 2 ELISA Kit; ADAMTS-like protein 2 ELISA Kit; ADAMTSL 2 ELISA Kit; ADAMTSL-2 ELISA Kit; ADAMTSL2 ELISA Kit; ATL2_HUMAN ELISA Kit; FLJ45164 ELISA Kit; KIAA0605 ELISA Kit
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縮寫：ADAMTSL2
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Uniprot No.：
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種屬：Homo sapiens (Human)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：3.12 ng/mL-200 ng/mL
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靈敏度：0.78 ng/mL
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反應(yīng)時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領(lǐng)域：Signal Transduction
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of human ADAMTSL2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 99 Range % 94-106 1:2 Average % 88 Range % 84-93 1:4 Average % 92 Range % 87-98 1:8 Average % 102 Range % 98-106 -
回收率：
The recovery of human ADAMTSL2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 91 87-96 EDTA plasma (n=4) 86 81-92 -
標(biāo)準(zhǔn)曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
ng/ml OD1 OD2 Average Corrected 200 1.854 1.988 1.921 1.812 100 1.262 1.192 1.227 1.118 50 0.780 0.733 0.757 0.648 25 0.487 0.451 0.469 0.360 12.5 0.312 0.334 0.323 0.214 6.25 0.231 0.217 0.224 0.115 3.12 0.169 0.160 0.165 0.056 0 0.109 0.108 0.109 -
數(shù)據(jù)處理：
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貨期：3-5 working days
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靶點詳情
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基因功能參考文獻(xiàn)：
- CpG-specific DNA methylation of ADAMTSL2 and BTN3A2 at rheumatoid arthritis diagnosis can serve as a marker of treatment response. PMID: 28447857
- Two compound heterozygous mutations were confirmed in the ADAMTSL2 gene of the patient with geleophysic dysplasia. PMID: 28917829
- A novel mutation in ADAMTSL2 (p. Gly421Ser) gene was identified in individuals with Ehlers-Danlos Syndrome. PMID: 26879370
- Two novel homozygous missense mutations in the ADAMTSL2 gene underlie geleophysic dysplasia in two consanguineous families from the United Arab Emirates. PMID: 24014090
- Molecular screening of ADAMTSL2 gene in 33 patients reveals the genetic heterogeneity of geleophysic dysplasia. PMID: 21415077
- These data suggest that ADAMTSL2 mutations may lead to a dysregulation of TGF-beta signaling and may be the underlying mechanism of geleophysic dysplasia. PMID: 18677313
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相關(guān)疾病：Geleophysic dysplasia 1 (GPHYSD1)
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亞細(xì)胞定位：Secreted.
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數(shù)據(jù)庫鏈接：
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