Dog thrombomodulin,TM ELISA Kit
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中文名稱:犬血栓調節蛋白(TM)酶聯免疫試劑盒
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貨號:CSB-E06529c
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規格:96T/48T
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價格:¥4200/¥3000
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其他:
產品詳情
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產品描述:犬血栓調節蛋白(TM)酶聯免疫試劑盒(CSB-E06529c)為競爭法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的THBD含量。THBD即凝血酶調節蛋白,它是血管內皮細胞表面的凝血酶受體。其背景上與凝血、炎癥等密切相關。研究機制方面,它能和凝血酶結合,改變其底物特異性,激活蛋白C,進而發揮抗凝、抗炎、保護血管內皮等作用,在多種疾病研究中有重要意義。試劑盒檢測范圍為23.44 pg/mL-1500 pg/mL,是研究犬類凝血功能異常、心血管疾病及炎癥相關機制的重要生物標志物;適用于科研領域中對犬類血栓形成機制、內皮功能障礙及藥物干預效果的體外研究,為動物模型實驗提供可靠的數據支持。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
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別名:THBD ELISA Kit; Thrombomodulin ELISA Kit; TM ELISA Kit; CD antigen CD141 ELISA Kit
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縮寫:
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Uniprot No.:
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種屬:Canis lupus familiaris (Dog) (Canis familiaris)
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樣本類型:serum, plasma, tissue homogenates
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檢測范圍:23.44 pg/mL-1500 pg/mL
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靈敏度:5.86 pg/mL
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反應時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領域:Cardiovascular
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測定原理:quantitative
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測定方法:Competitive
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度:
To assess the linearity of the assay, samples were spiked with high concentrations of dog TM in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:10 Average % 97 Range % 91-103 1:20 Average % 94 Range % 91-98 1:40 Average % 90 Range % 88-94 1:80 Average % 93 Range % 89-97 -
回收率:
The recovery of dog TM spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 89 83-94 EDTA plasma (n=4) 93 87-98 -
標準曲線:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. pg/ml OD1 OD2 Average 1500 0.087 0.086 0.087 750 0.148 0.142 0.145 375 0.234 0.229 0.232 187.5 0.347 0.338 0.343 93.75 0.562 0.576 0.569 46.88 0.865 0.921 0.893 23.44 1.464 1.392 1.428 0 2.677 2.568 2.623 -
數據處理:
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貨期:3-5 working days
相關產品
靶點詳情
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功能:Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
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基因功能參考文獻:
- plasma levels are higher in dogs infected with Leishmania infantum PMID: 15372989
- cDNA sequence analysis, amino acid sequence homology, and tissue expression. PMID: 15585960
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亞細胞定位:Membrane; Single-pass type I membrane protein.
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組織特異性:Expressed in lung, liver, spleen, kidney, pancreas and lymph node. Low expression in heart, cerebrum, urinary bladder and uterus.
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數據庫鏈接:
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