Bovine α Lactalbumin,α-La ELISA Kit
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中文名稱：牛α乳清蛋白(α-La)酶聯免疫試劑盒
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貨號：CSB-E13200B
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規格：96T/48T
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價格：￥4200/￥3000
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其他：
產品詳情
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產品描述：牛α乳清蛋白(α-La)酶聯免疫試劑盒（CSB-E13200B）為競爭法ELISA試劑盒，定量檢測血清、血漿樣本中的LALBA含量。牛α乳清蛋白（α-La）是乳清中第二大豐富的蛋白質，具有營養和生理功能。它作為研究蛋白質折疊的模型，對蛋白質物理化學性質研究有重要作用。α-La參與乳糖合成，與乳糖產生和乳分泌相關，同時具有結合金屬離子、抗菌和誘導細胞凋亡等功能。試劑盒檢測范圍為0.054 ng/ml- 40 ng/ml，靈敏度為0.054 ng/ml?？蒲蓄I域可用于探究乳源食品加工過程中蛋白質組分的變化、評估乳制品過敏性、監測反芻動物乳腺健康狀態，以及在食品工業中用于乳清蛋白產品的質量控制，為乳制品相關的基礎研究和應用開發提供可靠的技術支持。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：LALBA ELISA Kit; ALACTA ELISA Kit; Alpha-lactalbumin ELISA Kit; Lactose synthase B protein ELISA Kit; allergen Bos d 4 ELISA Kit
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縮寫：LALBA
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Uniprot No.：
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種屬：Bos taurus (Bovine)
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樣本類型：serum, plasma
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檢測范圍：0.054 ng/ml - 40 ng/ml
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靈敏度：0.054 ng/ml
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Metabolism
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測定原理：quantitative
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測定方法：Competitive
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精密度：
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線性度：
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回收率：
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標準曲線：
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數據處理：
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貨期：3-5 working days
產品評價
相關產品
靶點詳情
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功能：Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
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基因功能參考文獻：
- This study shows, for the first time, that alpha-lactalbumin isolated in a rare 28kDa dimeric form induces cell death, while 14kDa monomeric alpha-lactalbumin is inactive. PMID: 28193539
- Macromolecular crowding reduces the calcium binding affinity of holo-lactalbumin alpha resulting in the formation of apo-lactalbumin alpha (the calcium-depleted form of holo-LA) leading to aggregate formation. PMID: 25437004
- Data suggest that stabilization of apo-alpha-lactalbumin by mono- and oligo-saccharides can be accounted for by simplified statistical-thermodynamic model considering volume exclusion deriving from steric repulsion between protein and saccharides. PMID: 26000826
- These findings suggest that the SNP alpha-LA2516 in the alpha-LA gene likely does not have potential as a molecular marker for milk production traits in Chinese Holstein cows. PMID: 24065678
- alphaLA forms a misfolded disulfide bond shuffled isomer, X-alphaLA which represents a different low energy fold for the protein; binding calcium plays an important role in both maintaining the native structure of alphaLA and providing a mechanism for distinguishing between folded and misfolded species. PMID: 22189830
- Structural features of the alphaB-crystallin oligomer when complexed with target proteins under mild stress conditions, i.e., reduction of alpha-lactalbumin at 37 degrees C and malate dehydrogenase when heated at 42 degrees C, were investigated. PMID: 21152271
- the organization and dynamics of the functionally important tryptophan residues of BLA in native, molten globule and denatured states utilizing the wavelength-selective fluorescence approach were explored. PMID: 20346348
- The complexes formed by partially folded alpha-lactalbumin with oleic acid display selective apoptotic activity against tumor cells. PMID: 19968717
- a functional Ca(2+)-binding site is not required for conversion of alpha-lactalbumin to the active complex or to cause cell death PMID: 14627739
- Negatively charged alpha-lactalbumin (LA) interaction with basic histone stabilizes apo-alpha-LA and destabilizes the Ca2+-bound protein due to compensation for excess negative charge of alpha-LA's Ca2+-binding loop by positively charged histone residues. PMID: 15134431
- interaction of alphaB-cyrstallin with, and promoted unfolding of, reduced alpha-lactalbumin, but showed limited chaperone activity for other target proteins PMID: 15670152
- Data indicate that deletion of the beta-subdomain in alpha-lactalbumin does not alter the ability of the protein to assemble into well-ordered fibrils, implying that this chain region is not essential for the amyloid formation. PMID: 15853802
- Fold and topology of alpha-lactalbumin may be formed from degenerate groups of side chains. PMID: 15956205
- residual long-range interactions may act as nucleation sites for protein folding, while this property of residual structure is replaced by the calcium-binding site between the domains in alpha-lactalbumin. PMID: 16731974
- characterized the acid induced molten globule state (A-state) of alpha-LA both qualitatively and quantitatively. PMID: 16741984
- Results describe the reaction mechanism and formation of CIDNP (chemically induced dynamic nuclear polarization) in the photoreactions of the dye 2,2'-dipyridyl with non-native states of bovine and human alpha-lactalbumins in aqueous solution. PMID: 16851644
- interaction between calcium-depleted alpha-lactalbumin and lysozyme leads to the formation of different supramolecular structures depending on the temperature PMID: 17260954
- stopped-flow CD, fluorescence, and time-resolved NMR studies that the Ca(2+)-induced refolding of bovine alpha-lactalbumin (BLA) at constant denaturant concentration (4 M urea) exhibits triple-exponential kinetics. PMID: 18377934
- Allelic frequencies and RFLP patterns of alpha-lactalbumin gene vary between two species of cattle. PMID: 18607792
- Disulfide bond shuffling in bovine alpha-lactalbumin: MD simulation confirms experiment PMID: 18942855
- Serotonin suppressed alpha-lactalbumin mRNA expression in lactogen-treated primary bovine mammary epithelial cell cultures. PMID: 19654143
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亞細胞定位：Secreted.
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蛋白家族：Glycosyl hydrolase 22 family
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組織特異性：Mammary gland specific. Secreted in milk.
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