VDAC2
VDAC2，全稱電壓依賴性陰離子通道蛋白2，是一種位于線粒體外膜上的通道蛋白，也被稱為Anti-POR抗體。它參與細(xì)胞能量代謝和信號(hào)傳導(dǎo)，在腫瘤細(xì)胞的凋亡和免疫逃逸中發(fā)揮關(guān)鍵作用。研究表明，VDAC2高表達(dá)與免疫治療抵抗密切相關(guān)，敲除VDAC2基因能顯著增強(qiáng)現(xiàn)有免疫治療的效果，并克服免疫治療耐藥問(wèn)題。VDAC2缺失會(huì)導(dǎo)致癌細(xì)胞線粒體損傷，激活促凋亡蛋白BAK，引發(fā)細(xì)胞色素c釋放，進(jìn)而觸發(fā)I型干擾素應(yīng)答，加速癌細(xì)胞死亡。此外，VDAC2缺失還能重塑腫瘤微環(huán)境，增加殺傷性T細(xì)胞浸潤(rùn)，減少抑制性Treg細(xì)胞，將“冷腫瘤”轉(zhuǎn)化為免疫熱區(qū)，并形成長(zhǎng)期免疫記憶，提高免疫治療效果。目前，針對(duì)VDAC2開(kāi)發(fā)的候選藥物較少，多為小分子，主要用于心血管疾病治療，尚無(wú)針對(duì)腫瘤的藥物。VDAC2作為免疫治療的新靶點(diǎn)，對(duì)克服腫瘤免疫逃逸和耐藥具有重要意義。
熱銷產(chǎn)品
VDAC2 Antibody (CSB-PA025824LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA025824LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA025824LA01HU at dilution of 1:100
VDAC2 Antibodies
VDAC2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025824GA01HU | VDAC2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA025824LA01HU | VDAC2 Antibody | Human | ELISA, IHC |
| CSB-PA025824LB01HU | VDAC2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA025824LC01HU | VDAC2 Antibody, FITC conjugated | Human |
VDAC2 Proteins
VDAC2 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP025824RB CSB-EP025824RB CSB-BP025824RB CSB-MP025824RB CSB-EP025824RB-B |
Recombinant Rabbit Non-selective voltage-gated ion channel VDAC2 (VDAC2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VDAC2 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP025824BO CSB-EP025824BO CSB-BP025824BO CSB-MP025824BO CSB-EP025824BO-B |
Recombinant Bovine Voltage-dependent anion-selective channel protein 2 (VDAC2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VDAC2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP025824HU CSB-EP025824HU CSB-BP025824HU CSB-MP025824HU CSB-EP025824HU-B |
Recombinant Human Voltage-dependent anion-selective channel protein 2 (VDAC2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VDAC2 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP025824XBE CSB-EP025824XBE CSB-BP025824XBE CSB-MP025824XBE CSB-EP025824XBE-B |
Recombinant Xenopus laevis Voltage-dependent anion-selective channel protein 2 (vdac2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VDAC2 Proteins for Meleagris gallopavo (Common turkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP025824MQV CSB-EP025824MQV CSB-BP025824MQV CSB-MP025824MQV CSB-EP025824MQV-B |
Recombinant Meleagris gallopavo Voltage-dependent anion-selective channel protein 2 (VDAC2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VDAC2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP025824RA CSB-EP025824RA CSB-BP025824RA CSB-MP025824RA CSB-EP025824RA-B |
Recombinant Rat Voltage-dependent anion-selective channel protein 2 (Vdac2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VDAC2 Proteins for Mesocricetus auratus (Golden hamster)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP025824MRG CSB-EP025824MRG CSB-BP025824MRG CSB-MP025824MRG CSB-EP025824MRG-B |
Recombinant Mesocricetus auratus Voltage-dependent anion-selective channel protein 2 (VDAC2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VDAC2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-EP723359MO CSB-BP723359MO CSB-MP723359MO CSB-EP723359MO-B |
Recombinant Mouse Voltage-dependent anion-selective channel protein 2 (Vdac2), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VDAC2 Proteins for Oryza sativa subsp. japonica (Rice)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP743687OFG CSB-EP743687OFG CSB-BP743687OFG CSB-MP743687OFG CSB-EP743687OFG-B |
Recombinant Oryza sativa subsp. japonica Mitochondrial outer membrane protein porin 2 (VDAC2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VDAC2 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP861818DOA CSB-EP861818DOA CSB-BP861818DOA CSB-MP861818DOA CSB-EP861818DOA-B |
Recombinant Arabidopsis thaliana Mitochondrial outer membrane protein porin 2 (VDAC2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VDAC2 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP882001PI CSB-EP882001PI CSB-BP882001PI CSB-MP882001PI CSB-EP882001PI-B |
Recombinant Pig Voltage-dependent anion-selective channel protein 2 (VDAC2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
