TNFRSF8

CD30又名Ki-1抗原或腫瘤壞死因子受體超家族成員8（TNFRSF8），是一種跨膜糖蛋白受體。CD30與其配體（CD30L）結合可激活TNF受體相關因子（TRAF），進而激活不同信號通路，包括TRAF2、TRAF1、TRAF5來激活核因子-κB（NFκB）等等，促進細胞增殖或凋亡。CD30還參與絲裂原激活的蛋白激酶（MAPK）通路，包括ERK1和ERK2，從而在腫瘤細胞中發(fā)揮抗凋亡和促生存作用。CD30在正常組織中表達有限，而在多種血液腫瘤呈高表達，尤其在系統(tǒng)性間變性大細胞淋巴瘤（sALCL）和經(jīng)典型霍奇金淋巴瘤（cHL）呈高度、一致性表達。CD30的特異性表達使其具有了良好的成藥性，其中靶向CD30-ADC已經(jīng)大獲成功，2011年8月，CD30-ADC--維布妥昔單抗（brentuximabvedotin）首次在美國上市，用于治療霍奇金淋巴瘤和系統(tǒng)性間變性大細胞淋巴瘤。基于靶向CD30細胞療法的可行性，目前已經(jīng)相繼有多家制藥企業(yè)進行了CD30 CAR-T細胞藥物的研發(fā)，國內的波睿達生物、宜明細胞等均已獲得了相關發(fā)明專利授權。

Recombinant Human TNFRSF8 活性蛋白實驗驗證數(shù)據(jù)

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L(CSB-MP023996HU1c9), the EC₅₀ is 14.96-20.25 ng/ml.

TNFRSF8 Antibody

TNFRSF8 Protein

TNFRSF8 ELISA Kit

TNFRSF8 Antibodies

TNFRSF8 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA912411	TNFRSF8 Antibody	Human	ELISA,IHC
CSB-PA172042	TNFRSF8 Antibody	Human	ELISA,IHC

TNFRSF8 Proteins

TNFRSF8 Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP023983RA1 CSB-EP023983RA1 CSB-BP023983RA1 CSB-MP023983RA1 CSB-EP023983RA1-B	Recombinant Rat Tumor necrosis factor receptor superfamily member 8 (Tnfrsf8), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023983RA	Recombinant Rat Tumor necrosis factor receptor superfamily member 8 (Tnfrsf8)	in vitro E.coli expression system

TNFRSF8 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP023983HU1 CSB-EP023983HU1 CSB-BP023983HU1 CSB-EP023983HU1-B	Recombinant Human Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-CF023983HU	Recombinant Human Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)	in vitro E.coli expression system
CSB-MP023983HU1	Recombinant Human Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), partial (Active)	Mammalian cell
CSB-MP023983HU1h6	Recombinant Human Tumor necrosis factor receptor superfamily member 8(TNFRSF8), partial	Mammalian cell

TNFRSF8 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP723348MO CSB-EP723348MO CSB-BP723348MO CSB-MP723348MO CSB-EP723348MO-B	Recombinant Mouse Tumor necrosis factor receptor superfamily member 8 (Tnfrsf8), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli