TNFRSF14
皰疹病毒進入介體（Herpes virus entry mediator A，HVEM，又稱TNFRSF14）是TNF受體超家族成員，廣泛表達于APCs、內皮細胞和淋巴細胞，尤其是幼稚T細胞。HVEM與多種蛋白結合，包括LIGHT、TNF-β、BTLA和CD160。當HVEM與LIGHT或LTα結合時，傳遞共刺激信號，而HVEM與BTLA或CD160結合則觸發共抑制信號。因此，HVEM通常被描述為取決于所接合配體的分子開關。研究發現，HVEM在一些腫瘤中過表達，并且顯示腫瘤浸潤T細胞呈BTLA陽性。此外，HVEM的高表達與顯著較差的預后相關。腫瘤中HVEM上調代表了一種免疫逃逸機制，類似于腫瘤細胞過度表達PD-L1或PD-L2。根據轉錄組學分析，HVEM表達與免疫細胞浸潤和微環境中的基質細胞有關。HVEM的表達還與PD-1、PD-L1、CTLA-4、LAG-3和VISTA的表達相關。因此，HVEM在免疫和炎癥反應的調節中起著至關重要的作用，尤其是T細胞的激活。
Recombinant Human TNFRSF14 活性蛋白實驗驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized human TNFRSF14 at 5 μg/ml can bind Biotinylated human TNFSF14 (CSB-MP023991HUj7-B), the EC50 is 1.773-3.707 ng/ml.
TNFRSF14 Proteins
TNFRSF14 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP842173HU CSB-EP842173HU CSB-BP842173HU CSB-EP842173HU-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP002331HU | Recombinant Human Tumor necrosis factor receptor superfamily member 14 protein (TNFRSF14) | Yeast |
| CSB-MP842173HU | Recombinant Human Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), partial (Active) | Mammalian cell |
TNFRSF14 ELISA Kit
TNFRSF14 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL023973HU | Human Tumor necrosis factor receptor superfamily member 14(TNFRSF14) ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
