TGM2
組織型谷氨酰胺轉移酶2（TGM2）也被稱為TG2或組織轉谷氨酰胺酶，是一種多功能酶類蛋白。它廣泛分布于人體組織，通過催化蛋白質交聯參與細胞結構維持、損傷修復等生理過程，其活性受鈣離子濃度調控。該蛋白在細胞應激狀態下被激活，既能穩定胞外基質，也可進入細胞核影響基因表達，同時與炎癥因子釋放、免疫調節密切相關。TGM2的異常表達與器官纖維化進程、神經退行性疾病（如阿爾茨海默病）以及多種惡性腫瘤的侵襲轉移存在關聯。
在疾病干預領域，TGM2已成為纖維化疾病和特定癌癥的治療靶點。針對其開發的不可逆抑制劑如胱胺衍生物已進入臨床前研究，部分小分子化合物在動物模型中顯示出延緩肺纖維化進展的效果。該蛋白在腫瘤微環境中呈現雙重作用：既能促進癌細胞的耐藥性，又可抑制部分免疫細胞的抗腫瘤活性，這種復雜性為藥物研發帶來挑戰。當前研究正致力于開發具有組織選擇性的調控劑，以期在疾病治療中實現更精準的干預。
熱銷產品
Recombinant Human Protein-glutamine gamma-glutamyltransferase 2 (TGM2), partial (CSB-EP023462HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TGM2 Recombinant Monoclonal Antibody (CSB-RA147681A0HU)
驗證數據
Western Blot
Positive WB detected in: U87 whole cell lysate
All lanes: TGM2 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 78, 62, 39 kDa
Observed band size: 78 kDa
Human transglutaminase 2C polypeptide,TGM2 ELISA Kit (CSB-E11797h)
驗證數據
貨號：CSB-E11797h
規格：96T/48T
靈敏度：4.68 pg/mL
檢測范圍：18.75 pg/mL-1200 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
TGM2 Antibodies
TGM2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA11809A0Rb | TGM2 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA023462GA01HU | TGM2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-MA0234621A0m | TGM2 Monoclonal Antibody | Human | ELISA,WB,IHC |
| CSB-PA032600 | TGM2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA023462ESR1HU | TGM2 Antibody | Human | ELISA, IHC |
| CSB-PA023462ESR2HU | TGM2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA004272 | TGM2 Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA596121 | TGM2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA546098 | TGM2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-RA147681A0HU | TGM2 Recombinant Monoclonal Antibody | Human | ELISA, WB |
TGM2 Proteins
TGM2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023462HU CSB-BP023462HU CSB-MP023462HU CSB-EP023462HU-B |
Recombinant Human Protein-glutamine gamma-glutamyltransferase 2 (TGM2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP023462HU | Recombinant Human Protein-glutamine gamma-glutamyltransferase 2 (TGM2), partial | E.coli |
TGM2 ELISA Kit
TGM2 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11797h | Human transglutaminase 2C polypeptide,TGM2 ELISA Kit | serum, plasma, tissue homogenates | 4.68 pg/mL |
