TCF3
TCF3，即轉(zhuǎn)錄因子3，別名E2A免疫球蛋白增強(qiáng)子結(jié)合蛋白、B-cell-specific transcription factor 3 (Bcl-3) 等。TCF3是一種基本螺旋-環(huán)-螺旋 (bHLH) 結(jié)構(gòu)域的轉(zhuǎn)錄因子，屬于T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) 家族成員。它在多種細(xì)胞類型中都有表達(dá)，并且在細(xì)胞增殖、分化、遷移和凋亡等過程中發(fā)揮重要作用。TCF3的作用機(jī)制涉及到與多種蛋白質(zhì)和DNA序列的相互作用，能夠調(diào)控下游基因的表達(dá)。TCF3在生物學(xué)上的意義非常廣泛，它不僅參與了細(xì)胞的正常生理過程，還與多種疾病的發(fā)生發(fā)展密切相關(guān)。TCF3作為Wnt/β-catenin信號通路的主要效應(yīng)分子，通過與β-catenin相互作用調(diào)控靶基因的轉(zhuǎn)錄。在腫瘤細(xì)胞中，TCF3的表達(dá)水平和活性與腫瘤的侵襲性、轉(zhuǎn)移和耐藥性有關(guān)，使其成為癌癥治療的潛在靶點(diǎn)。此外，TCF3還在干細(xì)胞的維持和分化中發(fā)揮作用，影響組織再生和發(fā)育。因此，對TCF3的研究不僅有助于我們理解其在正常生理過程中的作用，也為疾病的診斷和治療提供了新的視角。
熱銷產(chǎn)品
驗證數(shù)據(jù)
Western blot analysis of extracts from 293 cells, using TCF3 antibody.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using TCF3 antibody.
TCF3 Antibodies
TCF3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023301GA01HU | TCF3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA123008 | Phospho-TCF3 (Thr355) Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA079787 | TCF3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA004248 | TCF3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA050218 | Phospho-TCF3 (T355) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA050219 | TCF3 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA023301HA01HU | TCF3 Antibody | Human | ELISA, IHC |
| CSB-PA023301HB01HU | TCF3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA023301HD01HU | TCF3 Antibody, Biotin conjugated | Human | ELISA |
TCF3 Proteins
TCF3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023301HU CSB-EP023301HU CSB-BP023301HU CSB-MP023301HU CSB-EP023301HU-B |
Recombinant Human Transcription factor E2-alpha (TCF3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TCF3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023301RA CSB-EP023301RA CSB-BP023301RA CSB-MP023301RA CSB-EP023301RA-B |
Recombinant Rat Transcription factor E2-alpha (Tcf3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TCF3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023301MO CSB-EP023301MO CSB-BP023301MO CSB-MP023301MO CSB-EP023301MO-B |
Recombinant Mouse Transcription factor E2-alpha (Tcf3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TCF3 Proteins for Mesocricetus auratus (Golden hamster)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023301MRG CSB-EP023301MRG CSB-BP023301MRG CSB-MP023301MRG CSB-EP023301MRG-B |
Recombinant Mesocricetus auratus Transcription factor E2-alpha (TCF3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
