Spike glycoprotein

S蛋白是一個很大的三聚體跨膜糖蛋白，它在病毒表面形成特殊的花冠結(jié)構(gòu)，得名于其獨特的形狀，即一系列突出的棘刺。S蛋白含有兩個功能亞基：S1和S2。S1亞基中有兩個基本結(jié)構(gòu)域，稱為受體結(jié)合域（RBD）和N端域（NTD）。S2具有三個域，分別稱為Heptad Repeat（HR）、Central Helix（CH）和Connector Domain（CD）。S蛋白的主要功能是幫助病毒進入和感染宿主細胞。它通過與宿主細胞表面的特定受體結(jié)合來實現(xiàn)這一點。在SARS-CoV-2的情況下，S蛋白與人體細胞表面的ACE2受體結(jié)合，從而啟動感染過程。S1亞基負責(zé)識別并結(jié)合宿主細胞表面的受體，而S2亞基則負責(zé)將病毒包膜與宿主細胞膜融合，使病毒內(nèi)的遺傳物質(zhì)得以注入細胞，達到感染的目的。 S蛋白的信號通路主要涉及其與宿主細胞受體的相互作用和膜融合過程。當(dāng)S蛋白的RBD區(qū)域與宿主細胞表面的ACE2受體結(jié)合后，會觸發(fā)一系列的細胞內(nèi)信號傳導(dǎo)事件。這些事件可能涉及細胞內(nèi)的多種分子和通路，最終導(dǎo)致病毒包膜與宿主細胞膜的融合，以及病毒遺傳物質(zhì)的釋放和感染過程的完成。全面地理解S蛋白在病毒感染過程中的作用機制，有利于開發(fā)針對冠狀病毒的疫苗和抗病毒藥物提供關(guān)鍵信息。

熱銷產(chǎn)品

● Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial (Active)

驗證數(shù)據(jù)

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Predicted band size: 51.1 kDa
Observed band size: 66 kDa due to glycosylation

ELISA

Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV-2-S1-RBD at 2 μg/ml can bind Biotinylated Anti-SARS-CoV-2-S Antibody (CSB-RA33245D1GMY), the EC₅₀ of SARS-CoV-2-S1-RBD protein is 106.2-131.2 ng/ml.

ELISA

Measured by its binding ability in a functional ELISA. Immobilized human ACE2 (CSB-MP866317HU) at 2 μg/ml can bind SARS-CoV-2-S1-RBD, the EC₅₀ of SARS-CoV-2-S1-RBD protein is 8.363-12.82 ng/ml.

● Recombinant Human SARS coronavirus Spike glycoprotein (S), partial (Active)

驗證數(shù)據(jù)

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV S-RBD at 2 μg/ml can bind Paguma larvata ACE2 (CSB-MP684964PAL), the EC₅₀ is 5.056-7.559 ng/ml.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV S-RBD at 5 μg/ml can bind human ACE2 (CSB-MP866317HU), the EC₅₀ is 7.941-10.49 ng/ml.

Spike glycoprotein Antibody

Spike glycoprotein Protein

Spike glycoprotein ELISA Kit

Spike glycoprotein Antibodies

Spike glycoprotein for Human coronavirus OC43

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA336163EA01HIY	S Antibody	Human coronavirus OC43	ELISA

Spike glycoprotein for Bovine coronavirus

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA333052LA01BJO	S Antibody	Bovine coronavirus	ELISA
CSB-PA333052LC01BJO	S Antibody, FITC conjugated	Bovine coronavirus
CSB-PA333052LD01BJO	S Antibody, Biotin conjugated	Bovine coronavirus	ELISA

Spike glycoprotein for Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-RA33245A0GMY	S Recombinant Monoclonal Antibody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA, GICA
CSB-RA33245A1GMY	S Recombinant Monoclonal Antibody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA, GICA, Neutralising
CSB-RA33245B1GMY	S Recombinant Monoclonal Antibody, HRP conjugated	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-RA33245C1GMY	S Recombinant Monoclonal Antibody, FITC conjugated	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)
CSB-RA33245D1GMY	S Recombinant Monoclonal Antibody, Biotin conjugated	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-RA33245A2GMY	SARS-CoV-2 Spike RBD Recombinant Nanobody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA, GICA, Neutralising
CSB-EAP33245	SARS-CoV-2 Spike RBD Antibody Pair 1	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	S-ELISA
CSB-RA33245B2GMY	SARS-CoV-2 Spike RBD Recombinant Nanobody, HRP conjugated	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-RA33245C2GMY	SARS-CoV-2 Spike RBD Recombinant Nanobody, FITC conjugated	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-RA33245D2GMY	SARS-CoV-2 Spike RBD Recombinant Nanobody, Biotin conjugated	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-MA33245A2m	S Monoclonal Antibody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-MA33245A1m	S Monoclonal Antibody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-MA33245A0m	S Monoclonal Antibody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-PA33245YA01GMY	S Antibody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-PA33245YD01GMY	S Antibody, Biotin conjugated	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-PA33245YA11GMY	S Antibody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-PA33245YB11GMY	S Antibody, HRP conjugated	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-PA33245YC11GMY	S Antibody, FITC conjugated	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)
CSB-PA33245YD11GMY	S Antibody, Biotin conjugated	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-EAP33255A1	SARS-CoV-2 N Antibody Pair 1	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	S-ELISA
CSB-EAP33255A2	SARS-CoV-2 N Antibody Pair 2	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	S-ELISA
CSB-EAP33255A3	SARS-CoV-2 N Antibody Pair 3	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	S-ELISA
CSB-EAP33255A4	SARS-CoV-2 N Antibody Pair 4	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	S-ELISA

Spike glycoprotein Proteins

Spike glycoprotein Proteins for Human coronavirus 229E (HCoV-229E)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP321366HIT CSB-BP321366HIT CSB-MP321366HIT CSB-EP321366HIT-B	Recombinant Human coronavirus 229E Spike glycoprotein (S), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP321366HIT	Recombinant Human coronavirus 229E Spike glycoprotein (S), partial	E.coli
CSB-MP321366HIT1	Recombinant Human coronavirus 229E Spike glycoprotein (S), partial	Mammalian cell

Spike glycoprotein Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP333052BJO	Recombinant Bovine coronavirus Spike glycoprotein (S), partial	Yeast
CSB-EP333052BJO	Recombinant Bovine coronavirus Spike glycoprotein (S), partial	E.coli

Spike glycoprotein Proteins for Human coronavirus OC43 (HCoV-OC43)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP336163HIY	Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial	Yeast
CSB-MP336163HIY CSB-EP336163HIY-B	Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial	Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP336163HIY	Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial	E.coli
CSB-EP336163HIY1	Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial	E.coli
CSB-BP336163HIY	Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial	Baculovirus
CSB-MP336163HIY1	Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial	Mammalian cell

Spike glycoprotein Proteins for Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-EP348663HQE CSB-BP348663HQE CSB-EP348663HQE-B	Recombinant Human SARS coronavirus Spike glycoprotein (S), partial	E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP348663HQE	Recombinant Severe acute respiratory syndrome coronavirus Spike glycoprotein (S), partial (Active)	Mammalian cell
CSB-YP348663HQE	Recombinant Human SARS coronavirus Spike glycoprotein (S), partial	Yeast
CSB-YP348663HQEa4	Recombinant Human SARS coronavirus Spike glycoprotein (S), partial	Yeast

Spike glycoprotein Proteins for Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP607323HIW CSB-BP607323HIW CSB-EP607323HIW-B	Recombinant Human coronavirus HKU1 Nucleoprotein (N)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP607323HIW	Recombinant Human coronavirus HKU1 Nucleoprotein (N)	E.coli
CSB-EP607323HIWc7	Recombinant Human coronavirus HKU1 Nucleoprotein (N)	E.coli
CSB-MP607323HIW	Recombinant Human coronavirus HKU1 Nucleoprotein (N)	Mammalian cell

Spike glycoprotein Proteins for Human coronavirus NL63 (HCoV-NL63)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-EP747509HIX CSB-BP747509HIX CSB-MP747509HIX CSB-EP747509HIX-B	Recombinant Human coronavirus NL63 Spike glycoprotein (S), partial	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP747509HIX1	Recombinant Human coronavirus NL63 Spike glycoprotein (S), partial	Yeast
CSB-YP747509HIX	Recombinant Human coronavirus NL63 Spike glycoprotein (S), partial	Yeast

Spike glycoprotein Proteins for Bovine coronavirus (strain vaccine) (BCoV) (BCV)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-BP333052BJO CSB-MP333052BJO CSB-EP333052BJO-B	Recombinant Bovine coronavirus Spike glycoprotein (S), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP333052BJOc7	Recombinant Bovine coronavirus Spike glycoprotein (S), partial	E.coli

Spike glycoprotein Proteins for Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-MP3324GMY	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial (Active)	Mammalian cell
CSB-MP3324GMY-B	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial	Mammalian cell
CSB-MP3324GMY1-B	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial,Biotinylated (Active)	Mammalian cell
CSB-MP3324GMY1	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial (Active)	Mammalian cell
CSB-YP3324GMY1	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial (Active)	Yeast
CSB-YP3324GMYa4	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial	Yeast
CSB-MP3324GMY1b1	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial (Active)	Mammalian cell
CSB-MP3324GMY(M1)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (D614G), partial (Active)	Mammalian cell
CSB-MP3324GMY1(M1)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (V367F), partial (Active)	Mammalian cell
CSB-MP3324GMY1(M2)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (W436R), partial (Active)	Mammalian cell
CSB-MP3324GMY1(M3)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (N354D,D364Y), partial	Mammalian cell
CSB-MP3324GMY1(M4)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (G476S), partial (Active)	Mammalian cell
CSB-MP3324GMY1(M5)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (V483A), partial (Active)	Mammalian cell
CSB-MP3324GMY1(M6)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (N501Y), partial (Active)	Mammalian cell
CSB-MP3324GMY(M2)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (N501Y,P681H), partial	Mammalian cell
CSB-MP3324GMY1(M6)k2	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (N501Y), partial (Active)	Mammalian cell
CSB-YP3324GMY2	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial	Yeast
CSB-MP3324GMY1(M7)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (K417N), partial	Mammalian cell
CSB-MP3324GMY1(M7)h8	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (K417N), partial	Mammalian cell
CSB-MP3324GMY1(M8)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (E484K), partial	Mammalian cell
CSB-MP3324GMY1(M8)h8	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (E484K), partial (Active)	Mammalian cell
CSB-MP3324GMY(M2)h8	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (N501Y,P681H), partial	Mammalian cell
CSB-MP3324GMY1(M10)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (K417N,E484K,N501Y), partial	Mammalian cell
CSB-MP3324GMY1(M9)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (K417T), partial	Mammalian cell
CSB-MP3324GMY1(M9)h8	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (K417T), partial	Mammalian cell
CSB-MP3324GMY(M4)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (Q677H), partial	Mammalian cell
CSB-MP3324GMY(M6)h8	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (K417N,E484K,N501Y), partial	Mammalian cell
CSB-MP3324GMY(M7)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (G75V,T76I,SYLTPGD247-253del,L452Q,F490S,D614G,T859N), partial	Mammalian cell
CSB-MP3324GMY1(M11)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (L452Q,F490S), partial	Mammalian cell
CSB-BP3324GMY1	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial	Baculovirus
CSB-MP3324GMY1(M12)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (L452Q,F490S), partial	Mammalian cell
CSB-MP3324GMY1(M12)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (L452Q,F490S), partial	Mammalian cell
CSB-MP3324GMY(M8)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S) (G75V,T76I,SYLTPGD247-253del), partial	Mammalian cell
CSB-BP3324GMY1c7	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial	Baculovirus
CSB-BP3324GMY1c7	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial	Baculovirus
CSB-EP3324GMY(M)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial	E.coli
CSB-YP3324GMY	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial	Yeast
CSB-MP3324GMY1k1-B	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial, Biotinylated	Mammalian cell
CSB-EP3324GMY14(M)e1	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial	E.coli
CSB-EP3324GMY14(M1)	Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial (L452R,T478K)	E.coli