STK11
STK11，即絲氨酸/蘇氨酸激酶11，也被稱(chēng)為L(zhǎng)KB1（Liver Kinase B1）。它是一種在人體多種組織中表達(dá)的蛋白質(zhì)，尤其在肝臟、腎臟和肺組織中。STK11的作用機(jī)制涉及作為蛋白激酶，通過(guò)磷酸化絲氨酸和蘇氨酸殘基，調(diào)控多種細(xì)胞過(guò)程，包括細(xì)胞極性、細(xì)胞周期、細(xì)胞增殖和細(xì)胞凋亡。STK11是LKB1-AMPK-mTOR信號(hào)通路的關(guān)鍵調(diào)節(jié)因子，通過(guò)激活A(yù)MPK（AMP激活蛋白激酶）來(lái)抑制mTOR（哺乳動(dòng)物雷帕霉素靶蛋白）信號(hào)通路，從而在能量平衡和細(xì)胞生長(zhǎng)中發(fā)揮作用。在生物學(xué)意義上，STK11作為腫瘤抑制基因，其突變與多種癌癥的發(fā)生發(fā)展有關(guān)，特別是在肺腺癌和胃腸道腫瘤中。STK11的活性喪失可能導(dǎo)致細(xì)胞周期失控和腫瘤形成，因此它在癌癥治療中是一個(gè)重要的靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
Recombinant Human Serine/threonine-protein kinase STK11 (STK11) (CSB-EP624036HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP624036HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) STK11.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP624036HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) STK11.
驗(yàn)證數(shù)據(jù)
Western Blot analysis of HT29 cells using LKB1 Polyclonal Antibody
Western Blot analysis of K562 cells using LKB1 Polyclonal Antibody
Western blot analysis of KB 3T3 Hela lysis using LKB1 antibody.
STK11 Antibodies
STK11 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA022833GA01HU | STK11 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA164495 | Phospho-STK11 (Thr189) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA902277 | Phospho-STK11 (Ser428) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA003156 | STK11 Antibody | Human,Mouse | WB, ELISA |
| CSB-PA003157 | STK11 Antibody | Human,Mouse | WB, ELISA |
| CSB-PA050177 | Phospho-STK11 (T189) Antibody | Human,Mouse | WB, ELISA |
| CSB-PA050178 | Phospho-STK11 (S428) Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA050179 | Phospho-STK11 (S334) Antibody | Human,Mouse | IHC, ELISA |
| CSB-PA050180 | STK11 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
STK11 Proteins
STK11 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP514278RA CSB-EP514278RA CSB-BP514278RA CSB-MP514278RA CSB-EP514278RA-B |
Recombinant Rat Serine/threonine-protein kinase STK11 (Stk11) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STK11 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP603578CH CSB-EP603578CH CSB-BP603578CH CSB-MP603578CH CSB-EP603578CH-B |
Recombinant Chicken Serine/threonine-protein kinase STK11 (STK11) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STK11 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP624036HU CSB-BP624036HU CSB-MP624036HU CSB-EP624036HU-B |
Recombinant Human Serine/threonine-protein kinase STK11 (STK11) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP624036HU | Recombinant Human Serine/threonine-protein kinase STK11 (STK11) | E.coli |
STK11 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP856244XBE CSB-EP856244XBE CSB-BP856244XBE CSB-MP856244XBE CSB-EP856244XBE-B |
Recombinant Xenopus laevis Serine/threonine-protein kinase stk11 (stk11) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STK11 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP893402MO CSB-EP893402MO CSB-MP893402MO CSB-EP893402MO-B |
Recombinant Mouse Serine/threonine-protein kinase STK11 (Stk11) | Yeast E.coli Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP893402MO | Recombinant Mouse Serine/threonine-protein kinase STK11 (Stk11) | Baculovirus |
