SREBF2
SREBF2，即固醇調(diào)節(jié)元件結(jié)合蛋白2，別名包括BHLHD2。SREBF2是一種關(guān)鍵的轉(zhuǎn)錄因子，主要在內(nèi)質(zhì)網(wǎng)膜上定位，通過感應(yīng)膽固醇水平的變化來調(diào)節(jié)膽固醇代謝相關(guān)基因的表達(dá)。SREBP2的作用機(jī)制涉及其在內(nèi)質(zhì)網(wǎng)中的感受膽固醇變化，當(dāng)膽固醇水平降低時，SREBP2從前體蛋白中被切割激活，然后轉(zhuǎn)移到細(xì)胞核內(nèi)，與固醇調(diào)節(jié)元件（SRE）結(jié)合，激活下游基因的轉(zhuǎn)錄，這些基因包括低密度脂蛋白受體（LDLR）、3-羥基-3-甲基戊二酰輔酶A還原酶（HMGCR）等，從而調(diào)節(jié)細(xì)胞內(nèi)膽固醇的合成和攝取。SREBP2是維持膽固醇穩(wěn)態(tài)的關(guān)鍵調(diào)控因子，對于細(xì)胞功能和機(jī)體健康至關(guān)重要。SREBP2的異常表達(dá)或活性失調(diào)可能導(dǎo)致多種代謝性疾病，包括動脈粥樣硬化、非酒精性脂肪肝病（NAFLD）等。
熱銷產(chǎn)品
SREBF2 Antibody (CSB-PA666241LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA666241LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA666241LA01HU at dilution of 1:100
Immunofluorescence staining of Hela cells with CSB-PA666241LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
SREBF2 Antibodies
SREBF2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA022658GA01HU | SREBF2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA552311 | SREBF2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA549727 | SREBF2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA666241LA01HU | SREBF2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA666241LC01HU | SREBF2 Antibody, FITC conjugated | Human | |
| CSB-PA666241LD01HU | SREBF2 Antibody, Biotin conjugated | Human | ELISA |
SREBF2 Proteins
SREBF2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP621515HU1 CSB-EP621515HU1 CSB-BP621515HU1 CSB-MP621515HU1 CSB-EP621515HU1-B |
Recombinant Human Sterol regulatory element-binding protein 2 (SREBF2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF621515HU | Recombinant Human Sterol regulatory element-binding protein 2 (SREBF2), partial | in vitro E.coli expression system |
