SRD5A2
SRD5A2，即類固醇5α-還原酶2，別名3-氧-5α-類固醇4-脫氫酶2、II型5α-還原酶等。它是一種微粒體酶，主要在人體中由SRD5A2基因編碼，高表達于對雄激素敏感的組織如前列腺。SRD5A2的作用機制是通過催化睪酮轉化為雙氫睪酮(DHT)，DHT與毛囊雄激素受體結合能力更強，這一過程對于性分化和雄激素生理學具有重要作用。此外，SRD5A2還參與了其他類固醇激素的代謝過程。SRD5A2在生物學上的意義非常廣泛，它不僅參與調節生殖系統的正常發育和功能，還與多種疾病相關。例如，SRD5A2基因的突變可導致男性假兩性畸形，特別是假陰道性會陰型尿道下裂。此外，SRD5A2的活性改變與前列腺癌的發展有關，其異常表達可能促進前列腺癌的進展。在藥物研究方面，SRD5A2抑制劑如非那雄胺和杜特列特等藥物已廣泛應用于治療前列腺增生等疾病。因此，SRD5A2是性激素相關疾病研究和治療中的一個重要靶點。
熱銷產品
Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2), partial (CSB-EP022654HU1)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2(SRD5A2) ELISA kit (CSB-EL022654HU)
驗證數據
貨號：CSB-EL022654HU
規格：96T/48T
靈敏度：6 pg/mL
檢測范圍：12 pg/mL-2400 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
SRD5A2 Proteins
SRD5A2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP022654HU1 CSB-BP022654HU1 CSB-MP022654HU1 CSB-EP022654HU1-B |
Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF022654HU | Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2) | in vitro E.coli expression system |
| CSB-EP022654HU1 | Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2), partial | E.coli |
| CSB-MP022654HU | Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)-VLPs | Mammalian cell |
SRD5A2 ELISA Kit
SRD5A2 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL022654HU | Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2(SRD5A2) ELISA kit | serum, plasma, tissue homogenates | 6 pg/mL |
