SMO
SMO，即平滑蛋白，別名Smoothened。它是一種細(xì)胞表面受體，屬于F類G蛋白偶聯(lián)受體（GPCR）家族成員，是Hedgehog（Hh）信號通路中的關(guān)鍵組分。SMO在細(xì)胞內(nèi)主要通過與Hh配體結(jié)合，被激活后能夠?qū)⑿盘杺鲗?dǎo)至細(xì)胞核，進(jìn)而激活GLI轉(zhuǎn)錄因子，調(diào)控相關(guān)基因的表達(dá)。SMO的來源是人體細(xì)胞自身的基因編碼，其作用機(jī)制涉及到與多種蛋白質(zhì)和脂質(zhì)分子的相互作用，尤其是膽固醇的共價修飾對SMO的功能至關(guān)重要 。SMO在生物學(xué)上的意義非常重大，它不僅參與調(diào)控胚胎發(fā)育、組織再生和器官修復(fù)等生理過程，而且與多種癌癥的發(fā)生發(fā)展密切相關(guān)。Hh信號通路在靜息狀態(tài)下，SMO受到Patched（PTCH）蛋白的抑制；當(dāng)Hh配體結(jié)合PTCH時，SMO受到的抑制被解除，從而激活下游信號通路。此外，SMO的異常激活與膠質(zhì)瘤等多種腫瘤的發(fā)生密切相關(guān)，因此，SMO成為了抗癌藥物開發(fā)的重要靶點 。
熱銷產(chǎn)品
驗證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA155823(SMO Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA155823(SMO Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
SMO Antibodies
SMO for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA050108 | SMO Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA155823 | SMO Antibody | Human,Rat | ELISA,IHC |
| CSB-PA857876LA01HU | SMO Antibody | Human, Mouse | ELISA, WB, IF |
| CSB-PA857876LB01HU | SMO Antibody, HRP conjugated | Human | ELISA |
| CSB-PA857876LC01HU | SMO Antibody, FITC conjugated | Human | |
| CSB-PA857876LD01HU | SMO Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA288930GA01HU | SMO Antibody | Human, Mouse, Rat | ELISA, WB |
SMO Proteins
SMO Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021841RA1 CSB-EP021841RA1 CSB-BP021841RA1 CSB-MP021841RA1 CSB-EP021841RA1-B |
Recombinant Rat Smoothened homolog (Smo), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF021841RA | Recombinant Rat Smoothened homolog (Smo) | in vitro E.coli expression system |
SMO Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021841MO1 CSB-EP021841MO1 CSB-BP021841MO1 CSB-MP021841MO1 CSB-EP021841MO1-B |
Recombinant Mouse Smoothened homolog (Smo), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF021841MO | Recombinant Mouse Smoothened homolog (Smo) | in vitro E.coli expression system |
SMO Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021841CH1 CSB-EP021841CH1 CSB-BP021841CH1 CSB-MP021841CH1 CSB-EP021841CH1-B |
Recombinant Chicken Smoothened homolog (SMO), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF021841CH | Recombinant Chicken Smoothened homolog (SMO) | in vitro E.coli expression system |
SMO Proteins for Drosophila melanogaster (Fruit fly)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP309724DLU CSB-EP309724DLU CSB-BP309724DLU CSB-MP309724DLU CSB-EP309724DLU-B |
Recombinant Drosophila melanogaster Protein smoothened (smo), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SMO Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP857876HU1 CSB-EP857876HU1 CSB-BP857876HU1 CSB-MP857876HU1 CSB-EP857876HU1-B |
Recombinant Human Smoothened homolog (SMO), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF857876HU | Recombinant Human Smoothened homolog (SMO) | in vitro E.coli expression system |
