SIRT6
SIRT6全稱為沉默調節(jié)蛋白6，是sirtuin家族成員之一，因其依賴輔酶NAD+發(fā)揮去乙酰化酶活性，又被稱作NAD依賴性組蛋白去乙酰化酶。SIRT6在基因組穩(wěn)定性維持和代謝調控中發(fā)揮核心作用，通過修復DNA損傷、調控糖脂代謝相關基因表達延緩細胞衰老進程。研究發(fā)現(xiàn)SIRT6缺失會引發(fā)早衰綜合征，其表達異常與肝癌、結腸癌等惡性腫瘤轉移密切相關，同時在Ⅱ型糖尿病、動脈粥樣硬化等代謝性疾病中呈現(xiàn)顯著下調趨勢。近年研究發(fā)現(xiàn)該蛋白可抑制NF-κB通路減輕慢性炎癥，并通過激活AMPK通路改善胰島素抵抗。當前針對SIRT6的藥物開發(fā)聚焦于小分子激活劑，如化合物MDL-800已在動物模型中證實可增強DNA修復能力并延長壽命，而部分天然產物如白藜蘆醇衍生物也顯示出調控潛力。隨著PROTAC等新技術的應用，靶向SIRT6的雙功能分子正成為抗衰老和癌癥治療領域的研究熱點。
熱銷產品
Recombinant Human NAD-dependent protein deacetylase sirtuin-6 (SIRT6) (CSB-EP854057HU)
驗證數(shù)據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗證數(shù)據
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse stomach tissue, Primary antibody: CSB-PA959450(SIRT6 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
SIRT6 Antibodies
SIRT6 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA021344GA01HU | SIRT6 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA854057ESR2HU | SIRT6 Antibody | Human | ELISA |
| CSB-PA959450 | SIRT6 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA113703 | SIRT6 Antibody | Human,Mouse | ELISA,WB |
SIRT6 Proteins
SIRT6 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP021344MO CSB-EP021344MO CSB-BP021344MO CSB-MP021344MO CSB-EP021344MO-B |
Recombinant Mouse NAD-dependent protein deacetylase sirtuin-6 (Sirt6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SIRT6 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP854057HU CSB-BP854057HU CSB-MP854057HU CSB-EP854057HU-B |
Recombinant Human NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP854057HU | Recombinant Human NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | E.coli |
SIRT6 ELISA Kit
SIRT6 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17018h | Human NAD-dependent deacetylase sirtuin-6 (SIRT6/SIR2L6) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.78 pg/mL |
