SIGLEC9
SIGLEC9，全稱為唾液酸結(jié)合免疫球蛋白樣凝集素9，是一種表達于人類細胞表面的蛋白質(zhì)，常見別名包括CDw329和CD329。該蛋白屬于免疫球蛋白超家族，具有結(jié)合唾液酸的能力，主要參與免疫調(diào)節(jié)。SIGLEC9在多種細胞類型中表達，包括巨噬細胞、樹突狀細胞和自然殺傷細胞等，通過與細胞表面唾液酸配體結(jié)合，影響免疫細胞的活性和功能。研究表明，SIGLEC9的表達與腫瘤微環(huán)境中的免疫抑制狀態(tài)密切相關(guān)，其在腫瘤細胞和免疫細胞之間的相互作用中發(fā)揮重要作用。
在疾病方面，SIGLEC9與多種癌癥的發(fā)生發(fā)展有關(guān)，如肝細胞癌、結(jié)直腸癌和乳腺癌等。藥物研發(fā)領(lǐng)域，針對SIGLEC9的靶向治療已成為研究熱點。例如，通過阻斷SIGLEC9與配體的結(jié)合，可以增強自然殺傷細胞的抗腫瘤活性，從而提高癌癥免疫治療的療效。此外，一些研究還發(fā)現(xiàn)，SIGLEC9的表達水平與腫瘤患者的預(yù)后相關(guān)，可作為評估腫瘤預(yù)后的生物標(biāo)志物。目前，針對SIGLEC9的抗體藥物和抑制劑正處于臨床研究階段，有望為癌癥患者提供新的治療選擇。
熱銷產(chǎn)品
Recombinant Human Sialic acid-binding Ig-like lectin 9 (SIGLEC9), partial (Active) (CSB-MP021303HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human SIGLEC9 at 2 μg/ml can bind Anti-SIGLEC9 recombinant antibody (CSB-RA021303MA1HU). The EC50 is 1.033-1.429 ng/mL.
SIGLEC9 Recombinant Monoclonal Antibody (CSB-RA021303MA1HU)
驗證數(shù)據(jù)
The Binding Activity of Human SIGLEC9 with Anti-SIGLEC9 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SIGLEC9 (CSB-MP021303HU) at 2 μg/mL can bind Anti-SIGLEC9 recombinant antibody. The EC50 is 1.033-1.429 ng/mL.
Human Sialic acid-binding Ig-like lectin 9(SIGLEC9) ELISA kit (CSB-EL021303HU)
驗證數(shù)據(jù)
貨號：CSB-EL021303HU
規(guī)格：96T/48T
靈敏度：31.25 pg/ml
檢測范圍：125 pg/ml-8000 pg/ml
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
SIGLEC9 Antibodies
SIGLEC9 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA021303GA01HU | SIGLEC9 Antibody | Human | ELISA,WB,IHC |
| CSB-PA923782 | SIGLEC9 Antibody | Human | ELISA,IHC |
| CSB-PA617106 | SIGLEC9 Antibody | Human | ELISA,WB,IHC |
| CSB-RA021303MA1HU | SIGLEC9 Recombinant Monoclonal Antibody | Human | ELISA |
SIGLEC9 Proteins
SIGLEC9 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-MP021303HU | Recombinant Human Sialic acid-binding Ig-like lectin 9 (SIGLEC9), partial (Active) | Mammalian cell |
SIGLEC9 ELISA Kit
SIGLEC9 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL021303HU | Human Sialic acid-binding Ig-like lectin 9(SIGLEC9) ELISA kit | serum,plasma,tissue homogenates. | 31.25 pg/ml |
