SELPLG
SELPLG，即選擇素P配體，別名CLA、CD162、PSGL1、PSGL-1，是一種由人類SELPLG基因編碼的糖蛋白，主要在骨髓細(xì)胞和受刺激的T淋巴細(xì)胞上表達(dá)。
SELPLG通過作為P-、E-和L-選擇素的高親和力反受體，介導(dǎo)白細(xì)胞與活化的血小板或表達(dá)選擇素的內(nèi)皮細(xì)胞的粘附，這一過程對于炎癥期間白細(xì)胞的運輸至關(guān)重要。SELPLG需要經(jīng)過酪氨酸硫酸化和O-連接的聚糖添加唾液酸Lewis x四糖(sLex)的翻譯后修飾，以實現(xiàn)其高親和力結(jié)合活性。SELPLG在先天性和適應(yīng)性免疫反應(yīng)中發(fā)揮關(guān)鍵作用，其異常表達(dá)和基因多態(tài)性與免疫反應(yīng)的缺陷有關(guān)。
熱銷產(chǎn)品
SELPLG Recombinant Monoclonal Antibody (CSB-RA567010A0HU)
驗證數(shù)據(jù)
IHC image of CSB-RA567010A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
SELPLG Antibodies
SELPLG for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006151 | SELPLG Antibody | Human | WB, ELISA |
| CSB-PA148952 | SELPLG Antibody | Human | ELISA,IHC |
| CSB-PA129120 | SELPLG Antibody | Human | ELISA,IHC |
| CSB-RA567010A0HU | SELPLG Recombinant Monoclonal Antibody | Human | ELISA, IHC |
SELPLG Proteins
SELPLG Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP621767HU CSB-EP621767HU CSB-BP621767HU CSB-MP621767HU CSB-EP621767HU-B |
Recombinant Human P-selectin glycoprotein ligand 1 (SELPLG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SELPLG Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP730777MO CSB-EP730777MO CSB-BP730777MO CSB-MP730777MO CSB-EP730777MO-B |
Recombinant Mouse P-selectin glycoprotein ligand 1 (Selplg), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
