SAV1
Protein salvador homolog 1 is a protein in humans that is encoded by SAV1 gene. Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues.
SAV1 Antibodies
SAV1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA020722GA01HU | SAV1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA875672ESR1HU | SAV1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA875672ESR2HU | SAV1 Antibody | Human, Mouse | ELISA, WB, IHC, IF, IP |
SAV1 Proteins
SAV1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP020722RA CSB-EP020722RA CSB-BP020722RA CSB-MP020722RA CSB-EP020722RA-B |
Recombinant Rat Protein salvador homolog 1 (Sav1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SAV1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP851839MO CSB-EP851839MO CSB-BP851839MO CSB-MP851839MO CSB-EP851839MO-B |
Recombinant Mouse Protein salvador homolog 1 (Sav1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SAV1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP875672HU CSB-EP875672HU CSB-BP875672HU CSB-MP875672HU CSB-EP875672HU-B |
Recombinant Human Protein salvador homolog 1 (SAV1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
