PSENEN
PSENEN，全稱為早老素增強(qiáng)子γ-分泌酶亞基（Presenilin enhancer gamma-secretase subunit），別名PEN-2、MDS033。PSENEN是γ-分泌酶復(fù)合體的核心組成之一，與早老素（PSEN1/PSEN2）、APH-1等蛋白共同參與跨膜蛋白的切割過程，例如淀粉樣前體蛋白（APP）經(jīng)其剪切后產(chǎn)生β淀粉樣蛋白，這類蛋白異常沉積與阿爾茨海默病的病理特征密切相關(guān)。PSENEN通過調(diào)控Notch受體的活化影響細(xì)胞分化與發(fā)育，其功能異常可能引發(fā)家族性黑蒙癡呆等罕見遺傳病。近年來研究發(fā)現(xiàn)，PSENEN基因突變還與某些皮膚腫瘤的發(fā)生相關(guān)。在藥物研發(fā)領(lǐng)域，針對γ-分泌酶復(fù)合體的抑制劑（如Semagacestat）曾進(jìn)入阿爾茨海默病臨床試驗(yàn)，但因干擾Notch通路引發(fā)嚴(yán)重副作用而終止。目前研究轉(zhuǎn)向開發(fā)選擇性調(diào)節(jié)劑，試圖在減少β淀粉樣蛋白生成的同時保留Notch信號功能，相關(guān)化合物如Nirogacestat已在乳腺癌和硬纖維瘤領(lǐng)域開展II期試驗(yàn)。
熱銷產(chǎn)品
Recombinant Human Gamma-secretase subunit PEN-2 (PSENEN) (CSB-CF878932HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PSENEN Antibody (CSB-PA878932OA01HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-PA878932OA01HU diluted at 1:400 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA878932OA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
PSENEN Antibodies
PSENEN for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA878932OA01HU | PSENEN Antibody | Human | ELISA, IHC |
| CSB-PA878932OB01HU | PSENEN Antibody, HRP conjugated | Human | ELISA |
| CSB-PA878932OC01HU | PSENEN Antibody, FITC conjugated | Human | |
| CSB-PA878932OD01HU | PSENEN Antibody, Biotin conjugated | Human | ELISA |
PSENEN Proteins
PSENEN Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP688881BO1 CSB-EP688881BO1 CSB-BP688881BO1 CSB-MP688881BO1 CSB-EP688881BO1-B |
Recombinant Bovine Gamma-secretase subunit PEN-2 (PSENEN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF688881BO | Recombinant Bovine Gamma-secretase subunit PEN-2 (PSENEN) | in vitro E.coli expression system |
PSENEN Proteins for Dictyostelium discoideum (Slime mold)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP690507DKK1 CSB-EP690507DKK1 CSB-BP690507DKK1 CSB-MP690507DKK1 CSB-EP690507DKK1-B |
Recombinant Dictyostelium discoideum Probable gamma-secretase subunit PEN-2 (psenen), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF690507DKK | Recombinant Dictyostelium discoideum Probable gamma-secretase subunit PEN-2 (psenen) | in vitro E.coli expression system |
PSENEN Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP757686RA1 CSB-EP757686RA1 CSB-BP757686RA1 CSB-MP757686RA1 CSB-EP757686RA1-B |
Recombinant Rat Gamma-secretase subunit PEN-2 (Psenen), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF757686RA | Recombinant Rat Gamma-secretase subunit PEN-2 (Psenen) | in vitro E.coli expression system |
PSENEN Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP812929DIL CSB-EP812929DIL CSB-BP812929DIL CSB-MP812929DIL CSB-EP812929DIL-B |
Recombinant Danio rerio Gamma-secretase subunit PEN-2 (psenen), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PSENEN Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP861450MO1 CSB-EP861450MO1 CSB-BP861450MO1 CSB-MP861450MO1 CSB-EP861450MO1-B |
Recombinant Mouse Gamma-secretase subunit PEN-2 (Psenen), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF861450MO | Recombinant Mouse Gamma-secretase subunit PEN-2 (Psenen) | in vitro E.coli expression system |
PSENEN Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP878932HU1 CSB-EP878932HU1 CSB-BP878932HU1 CSB-MP878932HU1 CSB-EP878932HU1-B |
Recombinant Human Gamma-secretase subunit PEN-2 (PSENEN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF878932HU | Recombinant Human Gamma-secretase subunit PEN-2 (PSENEN) | in vitro E.coli expression system |
