PRR5
Proline-rich protein 5 is a protein in humans that is encoded by PRR5 gene. Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.
PRR5 Antibodies
PRR5 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018796GA01HU | PRR5 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA977660 | PRR5 Antibody | Human,Mouse,Rat | ELISA,WB |
PRR5 Proteins
PRR5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018796HU CSB-EP018796HU CSB-BP018796HU CSB-MP018796HU CSB-EP018796HU-B |
Recombinant Human Proline-rich protein 5 (PRR5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PRR5 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP688861RA CSB-EP688861RA CSB-BP688861RA CSB-MP688861RA CSB-EP688861RA-B |
Recombinant Rat Proline-rich protein 5 (Prr5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PRR5 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP770524MO CSB-EP770524MO CSB-BP770524MO CSB-MP770524MO CSB-EP770524MO-B |
Recombinant Mouse Proline-rich protein 5 (Prr5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PRR5 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP807294XBE CSB-EP807294XBE CSB-BP807294XBE CSB-MP807294XBE CSB-EP807294XBE-B |
Recombinant Xenopus laevis Proline-rich protein 5 (prr5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
