OXSM
OXSM全稱(chēng)為線粒體3-氧酰基載體蛋白合酶(3-oxoacyl-ACP synthase mitochondrial),是脂肪酸β氧化途徑中的關(guān)鍵酶,負(fù)責(zé)催化中長(zhǎng)鏈脂肪酸的縮合反應(yīng)。OXSM也被稱(chēng)為KASIII或mtKAS,主要參與線粒體內(nèi)脂肪酸鏈的延長(zhǎng)過(guò)程,為細(xì)胞能量代謝提供原料。OXSM活性異常可能干擾脂質(zhì)穩(wěn)態(tài),導(dǎo)致線粒體功能障礙,與遺傳性代謝疾病如脂肪酸氧化障礙(FAOD)密切相關(guān),臨床表現(xiàn)為肌無(wú)力、低血糖和心肌病等。
近年來(lái),針對(duì)脂肪酸代謝通路的藥物開(kāi)發(fā)逐漸受到關(guān)注。雖然尚無(wú)直接靶向OXSM的上市藥物,但部分研究團(tuán)隊(duì)正探索通過(guò)調(diào)節(jié)脂肪酸合成酶家族成員來(lái)干預(yù)代謝性疾病。例如,某些糖尿病治療藥物可能間接影響OXSM相關(guān)代謝網(wǎng)絡(luò)。基因治療領(lǐng)域?qū)€粒體功能修復(fù)的研究,也為OXSM相關(guān)疾病的治療提供了新思路。由于OXSM在能量代謝中的特殊地位,其作為代謝綜合征或神經(jīng)退行性疾病的潛在靶點(diǎn)價(jià)值正在被重新評(píng)估。
熱銷(xiāo)產(chǎn)品
OXSM Antibody (CSB-PA868340LA01HU)
驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA868340LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA868340LA01HU at dilution of 1:100
OXSM Antibodies
OXSM for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
---|---|---|---|
CSB-PA017313GA01HU | OXSM Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA868340LA01HU | OXSM Antibody | Human | ELISA, IHC |
CSB-PA868340LB01HU | OXSM Antibody, HRP conjugated | Human | ELISA |
CSB-PA868340LC01HU | OXSM Antibody, FITC conjugated | Human | |
CSB-PA868340LD01HU | OXSM Antibody, Biotin conjugated | Human | ELISA |
OXSM Proteins
OXSM Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
---|---|---|
CSB-YP868340HU CSB-EP868340HU CSB-BP868340HU CSB-MP868340HU CSB-EP868340HU-B |
Recombinant Human 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (OXSM) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |