NR3C1
NR3C1，別名GRL、GCCR。這個基因位于人類第5號染色體上，編碼的糖皮質(zhì)激素受體在體內(nèi)幾乎每個細(xì)胞中都有表達(dá)，并且調(diào)節(jié)控制發(fā)育、新陳代謝和免疫反應(yīng)的基因。NR3C1的作用機(jī)制是通過與糖皮質(zhì)激素如皮質(zhì)醇結(jié)合，調(diào)節(jié)基因轉(zhuǎn)錄。未結(jié)合的受體存在于細(xì)胞的胞質(zhì)溶膠中，與糖皮質(zhì)激素結(jié)合后，受體-激素復(fù)合物可以進(jìn)入細(xì)胞核，通過反式激活或反式抑制的方式調(diào)節(jié)基因表達(dá)。NR3C1在應(yīng)對壓力源的短期和長期適應(yīng)中發(fā)揮作用，可能對理解心理障礙，包括抑郁癥和創(chuàng)傷后應(yīng)激障礙(PTSD)的某些或所有亞型至關(guān)重要。此外，NR3C1的異常表達(dá)與多種疾病的發(fā)生發(fā)展相關(guān)，如自身免疫疾病、代謝性疾病以及某些癌癥。
熱銷產(chǎn)品
Recombinant Human Glucocorticoid receptor (NR3C1), partial (CSB-EP016059HU1c2)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
NR3C1 Recombinant Monoclonal Antibody (CSB-RA958910A0HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: 293 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate, U87 whole cell lysate
All lanes: NR3C1 antibody at 1:1500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 86, 83, 82, 77, 76, 65, 61, 52, 51, 50 kDa
Observed band size: 95 kDa
Overlay histogram showing Jurkat cells stained with CSB-RA958910A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1μg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.
Human Glucocorticoid receptor(NR3C1) ELISA kit (CSB-EL016059HU)
驗證數(shù)據(jù)
貨號：CSB-EL016059HU
規(guī)格：96T/48T
靈敏度：7.81 pg/mL
檢測范圍：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
NR3C1 Antibodies
NR3C1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA016059KA01HU | NR3C1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA298129 | Phospho-NR3C1 (Ser226) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA784840 | NR3C1 (Ab-211) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA589113 | NR3C1 (Ab-226) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000363 | NR3C1 Antibody | Human,Mouse,Rat | WB |
| CSB-PA000689 | Phospho-NR3C1 (S211) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA008993 | Phospho-NR3C1 (S203) Antibody | Human,Mouse | WB, ELISA |
| CSB-PA008994 | Phospho-NR3C1 (S226) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA008996 | NR3C1 Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA008998 | NR3C1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA008999 | NR3C1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA866060 | NR3C1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA225804 | NR3C1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA869503 | NR3C1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA167985 | NR3C1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA016059LA01HU | NR3C1 Antibody | Human | ELISA, WB, IHC, IF, IP |
| CSB-PA016059LB01HU | NR3C1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA016059LC01HU | NR3C1 Antibody, FITC conjugated | Human | |
| CSB-PA016059LD01HU | NR3C1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA958910A0HU | NR3C1 Recombinant Monoclonal Antibody | Human | ELISA, WB, FC |
NR3C1 Proteins
NR3C1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP016059HU1 CSB-BP016059HU1 CSB-MP016059HU1 CSB-EP016059HU1-B |
Recombinant Human Glucocorticoid receptor (NR3C1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP016059HU1 | Recombinant Human Glucocorticoid receptor (NR3C1), partial | E.coli |
| CSB-EP016059HU1c2 | Recombinant Human Glucocorticoid receptor (NR3C1), partial | E.coli |
| CSB-EP016059HU1a2 | Recombinant Human Glucocorticoid receptor (NR3C1), partial | E.coli |
NR3C1 ELISA Kit
NR3C1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL016059HU | Human Glucocorticoid receptor(NR3C1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 7.81 pg/mL |
