NPC1
Niemann-Pick C1 proteinis a protein in humans that is encoded by NPC1 gene. Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. Binds oxysterol with higher affinity than cholesterol.
NPC1 Antibodies
NPC1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA015974GA01HU | NPC1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA948316 | NPC1 Antibody | Human | ELISA,IHC |
| CSB-PA890689LA01HU | NPC1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA890689LB01HU | NPC1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA890689LC01HU | NPC1 Antibody, FITC conjugated | Human | |
| CSB-PA890689LD01HU | NPC1 Antibody, Biotin conjugated | Human | ELISA |
NPC1 Proteins
NPC1 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015974PI CSB-EP015974PI CSB-BP015974PI CSB-MP015974PI CSB-EP015974PI-B |
Recombinant Pig Niemann-Pick C1 protein (NPC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NPC1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-EP015974HU CSB-BP015974HU CSB-MP015974HU CSB-EP015974HU-B |
Recombinant Human NPC intracellular cholesterol transporter 1 (NPC1), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP015974HU | Recombinant Human NPC intracellular cholesterol transporter 1 (NPC1), partial | Yeast |
NPC1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015974MO CSB-EP015974MO CSB-BP015974MO CSB-MP015974MO CSB-EP015974MO-B |
Recombinant Mouse Niemann-Pick C1 protein (Npc1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
