NES

NES，全名為核輸出序列蛋白，也被稱為核輸出序列。該蛋白在細胞核與細胞質之間的蛋白質運輸中發揮關鍵作用。NES蛋白通過識別并結合特定的核定位信號，將蛋白質從細胞核通過核孔復合體運輸到細胞質。這一過程對于維持細胞內蛋白質平衡和細胞功能至關重要。NES蛋白的異常與多種疾病相關，包括腫瘤、神經退行性疾病等。在藥物研發方面，針對NES蛋白的藥物正在研發中，旨在治療與NES蛋白功能異常相關的疾病。

熱銷產品

Recombinant Human Nestin (NES), partial (CSB-YP015713HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NES Monoclonal Antibody (CSB-MA0157131A0m)

驗證數據

Western Blot
Positive WB detected in: U251 whole cell lysate, SH-SY5Y whole cell lysate
All lanes: NES antibody at 3µg/ml
Secondary
Goat polyclonal to Mouse IgG at 1/10000 dilution
Predicted band size: 178 kDa
Observed band size: 260 kDa

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-MA0157131A0m at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-MA0157131A0m at dilution of 1:100

Immunohistochemistry of paraffin-embedded human melanoma using CSB-MA0157131A0m at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-MA0157131A0m at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L).

Immunofluorescent analysis of PC-3 cells using CSB-MA0157131A0m at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L).

Immunofluorescent analysis of U251 cells using CSB-MA0157131A0m at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L).

Overlay histogram showing U251 cells stained with CSB-MA0157131A0m (red line). The cells were fixed with 70% Ethylalcohol (18h) and then permeabilized with 0.3% Triton X-100 for 2 min. The cells were then incubated in 1x PBS /10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (10µg/1*10⁶cells) for 1 h at 4°C. The secondary antibody used was FITC goat anti-mouse IgG(H+L) at 1/200 dilution for 1 h at 4°C. Isotype control antibody (green line) was mouse IgG1 (10µg/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

Overlay histogram showing Hela cells stained with CSB-MA0157131A0m (red line). The cells were fixed with 70% Ethylalcohol (18h) and then permeabilized with 0.3% Triton X-100 for 2 min. The cells were then incubated in 1x PBS /10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (10µg/1*10⁶cells) for 1 h at 4°C. The secondary antibody used was FITC goat anti-mouse IgG(H+L) at 1/200 dilution for 1 h at 4°C. Isotype control antibody (green line) was mouse IgG1 (10µg/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

NES Antibody

NES Protein

NES Antibodies

NES for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-MA0157131A0m	NES Monoclonal Antibody	Human	ELISA, WB, IHC, IF, FC
CSB-PA094270	NES Antibody	Human	ELISA,IHC
CSB-PA558433	NES Antibody	Human	ELISA,IHC
CSB-PA137248	NES Antibody	Human	ELISA,IHC
CSB-PA015713YA01HU	NES Antibody	Human	ELISA, IHC, IF
CSB-PA015713YB01HU	NES Antibody, HRP conjugated	Human	ELISA
CSB-PA015713YC01HU	NES Antibody, FITC conjugated	Human
CSB-PA015713YD01HU	NES Antibody, Biotin conjugated	Human	ELISA

NES Proteins

NES Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP015713RA CSB-EP015713RA CSB-BP015713RA CSB-MP015713RA CSB-EP015713RA-B	Recombinant Rat Nestin (Nes), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NES Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP015713HU	Recombinant Human Nestin (NES), partial	Yeast
CSB-EP015713HU CSB-BP015713HU CSB-MP015713HU CSB-EP015713HU-B	Recombinant Human Nestin protein (NES), partial	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NES Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

產品貨號	產品名稱	來源
CSB-YP015713DIL CSB-EP015713DIL CSB-BP015713DIL CSB-MP015713DIL CSB-EP015713DIL-B	Recombinant Danio rerio Nestin (nes), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NES Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP015713MO CSB-EP015713MO CSB-BP015713MO CSB-MP015713MO CSB-EP015713MO-B	Recombinant Mouse Nestin (Nes), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NES Proteins for Mesocricetus auratus (Golden hamster)

產品貨號	產品名稱	來源
CSB-YP015713MRG CSB-EP015713MRG CSB-BP015713MRG CSB-MP015713MRG CSB-EP015713MRG-B	Recombinant Mesocricetus auratus Nestin (NES), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NES Proteins for Drosophila melanogaster (Fruit fly)

產品貨號	產品名稱	來源
CSB-YP893810DLU CSB-EP893810DLU CSB-BP893810DLU CSB-MP893810DLU CSB-EP893810DLU-B	Recombinant Drosophila melanogaster Transmembrane protein nessy (nes), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli