NCAPG2
NCAPG2，全稱為非SMC凝縮蛋白II復(fù)合體亞基G2，也被稱為染色體相關(guān)蛋白G2（CAP-G2）或亮氨酸 zipper 蛋白5（LUZP5）。該蛋白參與染色體凝縮和分離過程，確保細(xì)胞分裂時(shí)染色體正確分配。它主要在細(xì)胞周期的S期和G2/M期表達(dá)，其核心功能是幫助染色體在細(xì)胞分裂前正確凝縮，防止DNA纏結(jié)和斷裂。NCAPG2蛋白的表達(dá)水平異常可能影響基因組穩(wěn)定性，并與多種癌癥的發(fā)生密切相關(guān)，如乳腺癌、肺癌和結(jié)直腸癌。研究發(fā)現(xiàn)，NCAPG2過表達(dá)會(huì)加速細(xì)胞周期進(jìn)程，促進(jìn)腫瘤細(xì)胞增殖和轉(zhuǎn)移，而降低其表達(dá)則會(huì)導(dǎo)致染色體凝縮缺陷，引發(fā)細(xì)胞有絲分裂異常甚至凋亡。此外，NCAPG2還參與DNA損傷修復(fù)，其表達(dá)水平異常可能影響基因組穩(wěn)定性。目前，針對(duì)NCAPG2的研究主要集中在癌癥治療領(lǐng)域，探索通過調(diào)節(jié)其表達(dá)或功能來抑制腫瘤生長的可能性。
熱銷產(chǎn)品
NCAPG2 Antibody (CSB-PA572077)
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA572077(NCAPG2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA572077(NCAPG2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
NCAPG2 Antibodies
NCAPG2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA030150 | NCAPG2 Antibody | Human | IHC, ELISA |
| CSB-PA572077 | NCAPG2 Antibody | Human | ELISA,IHC |
NCAPG2 Proteins
NCAPG2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP801255HU CSB-EP801255HU CSB-BP801255HU CSB-MP801255HU CSB-EP801255HU-B |
Recombinant Human Condensin-2 complex subunit G2 (NCAPG2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
