MS4A1
MS4A1基因編碼CD20蛋白，該抗原為一種疏水性4次跨膜蛋白，分子量大約為35kDa。CD20也叫B淋巴細胞表面抗原B1、Bp35、白細胞表面抗原Leu-16等等。CD20只在B淋巴細胞上表達，參與調(diào)節(jié)B細胞活化和增殖，作為鈣離子通道發(fā)揮作用。除在正常B細胞中表達外，CD20還在B細胞來源的淋巴瘤、白血病等的腫瘤細胞表達，以及涉及免疫疾病和炎癥疾病的B細胞中表達，所以CD20抗原成為淋巴癌、白血病和某些自體免疫等疾病治療的目標靶點。目前，針對這些疾病的CD20治療主要有三種方式，包括抗CD20單克隆抗體、CAR-T和雙特異性抗體。自1997年全球首款抗CD20單抗——羅氏的利妥昔單抗獲批以來，全球已經(jīng)批準多款抗CD20單抗。相關數(shù)據(jù)統(tǒng)計顯示，目前有高達90多種針對CD20的生物制劑處于臨床開發(fā)階段。
CUSABIO-哺乳包膜VLPs平臺成功開發(fā)MS4A1全長膜蛋白（4次跨膜），展示了完整生物活性。
熱銷產(chǎn)品
● Recombinant Human B-lymphocyte antigen CD20(MS4A1)-VLPs (Active) CSB-MP015007HU
驗證數(shù)據(jù)
CSB-MP015007HU is detected by Mouse anti-6*His monoclonal antibody.
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL.
by TEM
The presence of VLP-like structures was confirmed by TEM.
● MS4A1 Recombinant Monoclonal Antibody CSB-RA015007MA4HU
驗證數(shù)據(jù)
IHC image of CSB-RA015007MA4HU diluted at 1:200 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB
Immunofluorescence staining of Hela cell with CSB-RA015007MA4HU at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L)
Immunofluorescence staining of MCF7 cell with CSB-RA015007MA4HU at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG (H+L)
MS4A1 Antibodies
MS4A1 for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA015007LD01MO | Ms4a1 Antibody, Biotin conjugated | Mouse | ELISA |
| CSB-PA015007LC01MO | Ms4a1 Antibody, FITC conjugated | Mouse | |
| CSB-PA015007LB01MO | Ms4a1 Antibody, HRP conjugated | Mouse | ELISA |
| CSB-PA015007LA01MO | Ms4a1 Antibody | Mouse, Human | ELISA, WB |
MS4A1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA015007DSR2HU | MS4A1 Antibody | Human | ELISA, IHC |
| CSB-PA001433 | MS4A1 Antibody | Human | WB, ELISA |
| CSB-PA006161 | MS4A1 Antibody | Human | WB, ELISA |
| CSB-RA015007A0HU | CD20 Recombinant Monoclonal Antibody | Human | ELISA |
| CSB-MA996413 | MS4A1 Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA015007A1HU | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA |
| CSB-RA015007MA3HU | MS4A1 Recombinant Monoclonal Antibody | Human, Dog, Macaca fascicularis | ELISA |
| CSB-RA015007MA4HU | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
MS4A1 for H, M, R
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-MA000204 | MS4A1 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
MS4A1 Proteins
MS4A1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP661636DO1 CSB-BP661636DO1 CSB-MP661636DO1 CSB-EP661636DO1-B |
Recombinant Dog B-lymphocyte antigen CD20 (MS4A1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF661636DO | Recombinant Dog B-lymphocyte antigen CD20 (MS4A1) | in vitro E.coli expression system |
MS4A1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP015007MO2 | Recombinant Mouse B-lymphocyte antigen CD20 (Ms4a1), partial | E.coli |
| CSB-YP015007MO2 | Recombinant Mouse B-lymphocyte antigen CD20 (Ms4a1), partial | Yeast |
| CSB-YP015007MO1 | Recombinant Mouse B-lymphocyte antigen CD20 (Ms4a1), partial | Yeast |
| CSB-CF015007MO | Recombinant Mouse B-lymphocyte antigen CD20 (Ms4a1) | in vitro E.coli expression system |
| CSB-BP015007MO2 CSB-MP015007MO2 CSB-EP015007MO2-B |
Recombinant Mouse B-lymphocyte antigen CD20 (Ms4a1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP015007MO1 CSB-BP015007MO1 CSB-MP015007MO1 CSB-EP015007MO1-B |
Recombinant Mouse B-lymphocyte antigen CD20 (Ms4a1), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MS4A1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015007HU1 | Recombinant Human B-lymphocyte antigen CD20 (MS4A1), partial | Yeast |
| CSB-CF015007HU | Recombinant Human B-lymphocyte antigen CD20 (MS4A1) | in vitro E.coli expression system |
| CSB-EP015007HU1 CSB-BP015007HU1 CSB-MP015007HU1 CSB-EP015007HU1-B |
Recombinant Human B-lymphocyte antigen CD20 (MS4A1), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP015007HU | Recombinant Human B-lymphocyte antigen CD20 (MS4A1)-VLPs (Active) | Mammalian cell |
| CSB-EP015007HU2 | Recombinant Human B-lymphocyte antigen CD20 (MS4A1), partial | E.coli |
| CSB-MP015007HU-D | Recombinant Human B-lymphocyte antigen CD20(MS4A1)-Detergent (Active) | Mammalian cell |
MS4A1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-MP661636DO | Recombinant Dog B-lymphocyte antigen CD20 (MS4A1)-VLPs (Active) | Mammalian cell |
| CSB-EP661636DO1 | Recombinant Canis lupus familiaris B-lymphocyte antigen CD20 (MS4A1), partial | E.coli |
MS4A1 ELISA Kit
MS4A1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14007h | Human B-lymphocyte antigen (CD20) ELISA Kit | serum, plasma, tissue homogenates | 0.78 ng/mL |
