MERTK
MERTK，即MER原癌基因酪氨酸激酶（MerTK），別名PROS1R、TYRO3、Axl-likeprotein等。它是一種受體酪氨酸激酶，屬于TAM（TYRO3、AXL、MERTK）家族成員之一。MERTK在多種組織中表達(dá)，包括巨噬細(xì)胞和視網(wǎng)膜色素上皮細(xì)胞。其作用機(jī)制涉及與磷脂酰絲氨酸（PS）暴露的凋亡細(xì)胞結(jié)合，介導(dǎo)巨噬細(xì)胞的吞噬作用，促進(jìn)細(xì)胞凋亡的清除，同時(shí)參與調(diào)節(jié)炎癥反應(yīng)和免疫應(yīng)答。MERTK對(duì)于維持組織穩(wěn)態(tài)、促進(jìn)損傷修復(fù)、調(diào)節(jié)免疫反應(yīng)具有重要作用。MERTK的異常表達(dá)與多種疾病相關(guān)，包括視網(wǎng)膜色素變性、某些類型的癌癥以及免疫相關(guān)疾病。在腫瘤微環(huán)境中，MERTK的表達(dá)與腫瘤免疫逃逸有關(guān)，通過(guò)調(diào)節(jié)腫瘤相關(guān)巨噬細(xì)胞（TAMs）的吞噬作用，影響腫瘤免疫原性和抗腫瘤免疫。MERTK是癌癥治療中一個(gè)潛在的藥物靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Tyrosine-protein kinase Mer (MERTK), partial (Active) (CSB-MP621519HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized MERTK at 2 μg/ml can bind anti-MERTK antibody（CSB-RA621519A1HU）, the EC50 is 32.95-48.25 ng/mL.
MERTK Recombinant Monoclonal Antibody (CSB-RA621519A1HU)
驗(yàn)證數(shù)據(jù)
The Binding Activity of MERTK with anti-MERTK antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized MERTK at 2 μg/mL can bind anti-MERTK antibody(CSB-RA621519A1HU), the EC50 is 41.31-72.08 ng/mL.
MERTK Antibodies
MERTK for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA253602 | MERTK Antibody | Human | ELISA,WB |
| CSB-PA621519ESR1HU | MERTK Antibody | Human, Mouse | ELISA, WB |
| CSB-PA621519ESR2HU | MERTK Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA003228 | MERTK Antibody | Human | WB, ELISA |
| CSB-PA999740 | MERTK Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA668039 | MERTK Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA621519A1HU | MERTK Recombinant Monoclonal Antibody | Human | ELISA |
| CSB-MA621519A0m | MERTK Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC |
MERTK Proteins
MERTK Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP013706RA CSB-EP013706RA CSB-BP013706RA CSB-EP013706RA-B |
Recombinant Rat Tyrosine-protein kinase Mer (Mertk), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP013706RA | Recombinant Rat Tyrosine-protein kinase Mer (Mertk), partial | Mammalian cell |
MERTK Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP621519HU CSB-EP621519HU CSB-BP621519HU CSB-EP621519HU-B |
Recombinant Human Tyrosine-protein kinase Mer (MERTK), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP621519HU | Recombinant Human Tyrosine-protein kinase Mer (MERTK), partial (Active) | Mammalian cell |
MERTK Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP723346MO1 CSB-EP723346MO CSB-BP723346MO CSB-EP723346MO1-B |
Recombinant Mouse Tyrosine-protein kinase Mer (Mertk), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP723346MO | Recombinant Mouse Tyrosine-protein kinase Mer (Mertk), partial (Active) | Mammalian cell |
