MED12
MED12，全稱為Mediator complex subunit 12，是介導復合物的重要組成部分，參與調(diào)控轉(zhuǎn)錄起始。該蛋白與CDK8亞復合體結合，協(xié)同調(diào)控基因表達。MED12常見別名包括FG syndrome亞基、Lujan-Fryns綜合征亞基等。在免疫系統(tǒng)中，MED12對T細胞的休息與激活起著關鍵作用，協(xié)調(diào)T細胞功能的平衡。其異常表達與基底樣胰腺癌等癌癥相關，影響癌癥進展及治療耐藥性。此外，MED12基因突變會導致X連鎖Opitz-Kaveggia綜合征，表現(xiàn)為智力障礙、面部特征異常等。目前，針對MED12相關疾病的研究正在推進，包括開發(fā)針對基底樣胰腺癌的小分子抑制劑，以及探索其在自身免疫性疾病治療中的應用。藥物研發(fā)進展主要集中在靶向MED12突變的治療策略，以期改善癌癥免疫療法的效果。
熱銷產(chǎn)品
MED12 Antibody (CSB-PA853101LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA853101LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA853101LA01HU at dilution of 1:100
MED12 Antibodies
MED12 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA013643GA01HU | MED12 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA229024 | MED12 Antibody | Human | ELISA,IHC |
| CSB-PA080112 | MED12 Antibody | Human | IHC, ELISA |
| CSB-PA161569 | MED12 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA936493 | MED12 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA259630 | MED12 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA833160 | MED12 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA853101LA01HU | MED12 Antibody | Human | ELISA, IHC |
| CSB-PA853101LC01HU | MED12 Antibody, FITC conjugated | Human | |
| CSB-PA853101LD01HU | MED12 Antibody, Biotin conjugated | Human | ELISA |
MED12 Proteins
MED12 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013643MO CSB-EP013643MO CSB-BP013643MO CSB-MP013643MO CSB-EP013643MO-B |
Recombinant Mouse Mediator of RNA polymerase II transcription subunit 12 (Med12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MED12 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP652404DIL CSB-EP652404DIL CSB-BP652404DIL CSB-MP652404DIL CSB-EP652404DIL-B |
Recombinant Danio rerio Mediator of RNA polymerase II transcription subunit 12 (med12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MED12 Proteins for Dictyostelium discoideum (Slime mold)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP703859DKK CSB-EP703859DKK CSB-BP703859DKK CSB-MP703859DKK CSB-EP703859DKK-B |
Recombinant Dictyostelium discoideum Putative mediator of RNA polymerase II transcription subunit 12 (med12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MED12 Proteins for Pongo pygmaeus (Bornean orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP716187EXP CSB-EP716187EXP CSB-BP716187EXP CSB-MP716187EXP CSB-EP716187EXP-B |
Recombinant Pongo pygmaeus Mediator of RNA polymerase II transcription subunit 12 (MED12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MED12 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP801771EQV CSB-EP801771EQV CSB-BP801771EQV CSB-MP801771EQV CSB-EP801771EQV-B |
Recombinant Pan troglodytes Mediator of RNA polymerase II transcription subunit 12 (MED12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MED12 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP853101HU CSB-EP853101HU CSB-BP853101HU CSB-MP853101HU CSB-EP853101HU-B |
Recombinant Human Mediator of RNA polymerase II transcription subunit 12 (MED12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
