LILRA4
LILRA4全稱為白細(xì)胞免疫球蛋白樣受體亞家族A成員4，也被稱為ILT7或CD85g，屬于免疫球蛋白樣受體家族成員。LILRA4主要表達(dá)于漿細(xì)胞樣樹突狀細(xì)胞表面，通過與特定配體結(jié)合發(fā)揮免疫調(diào)節(jié)功能。LILRA4能識(shí)別病毒核酸復(fù)合物，在抗病毒免疫中通過調(diào)控I型干擾素分泌維持免疫平衡，其異常表達(dá)可能導(dǎo)致系統(tǒng)性紅斑狼瘡等自身免疫疾病的發(fā)生發(fā)展。LILRA4在腫瘤微環(huán)境中呈現(xiàn)差異性表達(dá)特征，與乳腺癌、淋巴瘤等惡性腫瘤的免疫逃逸現(xiàn)象存在關(guān)聯(lián)。近年針對(duì)LILRA4的藥物研發(fā)聚焦于調(diào)節(jié)其信號(hào)活性，包括開發(fā)靶向抗體和受體阻斷劑，其中部分候選藥物已進(jìn)入臨床前研究階段。LILRA4與同家族成員LILRB4在功能上存在交叉性，這為開發(fā)廣譜免疫治療策略提供了新思路。
熱銷產(chǎn)品
LILRA4 Recombinant Monoclonal Antibody (CSB-RA012936MA1HU)
驗(yàn)證數(shù)據(jù)
Western Blot Positive WB detected in:Hela whole cell lysate (20μg), HpeG2 whole cell lysate (20μg), Jurkat whole cell lysate (20μg), K562 whole cell lysate (20μg) All lanes: LILRA4 antibody at 1:1000 Secondary Goat polyclonal to human IgG at 1/40000 dilution Predicted band size:55.18, 47.81 kDa Observed band size:50 kDa Exposure time:20s
IHC image of CSB-RA012936MA1HU diluted at 1:100 and staining in paraffin-embedded human skin tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
LILRA4 Antibodies
LILRA4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012936GA01HU | LILRA4 Antibody | Human | ELISA,WB |
| CSB-PA005237 | LILRA4 Antibody | Human | WB, ELISA |
| CSB-PA012936LA01HU | LILRA4 Antibody | Human | ELISA, IHC, IF |
| CSB-PA012936LD01HU | LILRA4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA012936LB01HU | LILRA4 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA012936MA1HU | LILRA4 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
LILRA4 Proteins
LILRA4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012936HU1 CSB-EP012936HU1 CSB-BP012936HU1 CSB-EP012936HU1-B |
Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF012936HU | Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4) | in vitro E.coli expression system |
