LGALS3BP
LGALS3BP編碼的蛋白全稱為半乳糖凝集素-3結合蛋白（Galectin-3 binding protein），常被簡稱為MAC-2BP或90K蛋白，在UniProt數據庫中也被標注為Lectin galactoside-binding soluble 3 binding protein。該蛋白是一種分泌型糖蛋白，廣泛參與細胞間相互作用與免疫調節，通過與半乳糖凝集素家族成員（如Galectin-3）結合，介導細胞黏附、炎癥反應及腫瘤微環境調控。研究發現其在多種癌癥中異常高表達，包括乳腺癌、肺癌和肝癌，可能與腫瘤轉移、血管生成及免疫逃逸相關。此外，該蛋白在病毒感染中發揮雙重作用，既能通過增強干擾素應答抑制HIV復制，又能作為HCV病毒顆粒的附著因子促進感染。在自身免疫性疾病如系統性紅斑狼瘡患者血清中，其水平顯著升高。近年來，針對LGALS3BP的藥物開發聚焦于癌癥治療領域，已有單克隆抗體藥物進入臨床前研究，試圖通過阻斷其與Galectin-3的相互作用抑制腫瘤進展。同時，其作為生物標志物的潛力也在液體活檢技術中受到關注，特別是在肝癌早期診斷和預后評估方面顯示出應用價值。
熱銷產品
Recombinant Human Galectin-3-binding protein (LGALS3BP) (CSB-EP012888HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
LGALS3BP Antibody (CSB-PA594413)
驗證數據
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA594413(LGALS3BP Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA594413(LGALS3BP Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
Human Galectin-3-binding protein(LGALS3BP) ELISA kit (CSB-EL012888HU)
驗證數據
貨號：CSB-EL012888HU
規格：96T/48T
靈敏度：0.39 ng/mL
檢測范圍：1.56 ng/mL-100 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
LGALS3BP Antibodies
LGALS3BP for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA012888GA01HU | LGALS3BP Antibody | Human | ELISA,WB |
| CSB-PA594413 | LGALS3BP Antibody | Human | ELISA,IHC |
| CSB-PA667994 | LGALS3BP Antibody | Human,Mouse | WB,ELISA |
LGALS3BP Proteins
LGALS3BP Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-EP012888HU | Recombinant Human Galectin-3-binding protein (LGALS3BP) | E.coli |
LGALS3BP ELISA Kit
LGALS3BP ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL012888HU | Human Galectin-3-binding protein(LGALS3BP) ELISA kit | serum, plasma, tissue homogenates | 0.39 ng/mL |
