L1CAM
L1細(xì)胞黏附分子（L1 cell adhesion molecule，L1CAM）是免疫球蛋白超家族中的一種神經(jīng)黏附蛋白，以膜蛋白和游離蛋白的形式存在。L1CAM廣泛存在于神經(jīng)中樞系統(tǒng)，在神經(jīng)系統(tǒng)發(fā)育過程中起著重要作用。此外，L1CAM作為一種神經(jīng)粘附分子，可以調(diào)節(jié)腫瘤細(xì)胞的生長和遷移。大量研究表明，許多類型的癌細(xì)胞若要成功轉(zhuǎn)移至其他正常器官內(nèi)，L1CAM分子必不可少。通常，正常的健康組織不會(huì)產(chǎn)生L1CAM，但晚期癌癥常常會(huì)伴隨著L1CAM的產(chǎn)生。L1CAM抑制劑可阻滯體外腫瘤細(xì)胞的增殖和遷移并增加腫瘤細(xì)胞的化療敏感性。 相關(guān)數(shù)據(jù)表明，患有腫瘤的小鼠使用L1CAM抗體治療，可抑制腫瘤的擴(kuò)散。因此，L1CAM在腫瘤生成和作為抗癌治療靶點(diǎn)上都有重要意義。
Recombinant Human L1CAM 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized L1CAM at 2 μg/ml can bind Anti-L1CAM Rabbit Monoclonal Antibody (CSB-RA595071A0HU), the EC50 is 5.384-9.380 ng/ml.
L1CAM Antibodies
L1CAM for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA07439A0Rb | L1CAM Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA07439B0Rb | L1CAM Antibody, HRP conjugated | Human | ELISA |
| CSB-PA07439D0Rb | L1CAM Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA003380 | L1CAM Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA009695 | Phospho-L1CAM (S1181) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA078460 | L1CAM Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA266419 | L1CAM Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-RA588962A0HU | L1CAM Recombinant Monoclonal Antibody | Human | ELISA, IHC, FC |
L1CAM Proteins
L1CAM Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012704MO CSB-EP012704MO CSB-BP012704MO CSB-EP012704MO-B |
Recombinant Mouse Neural cell adhesion molecule L1 (L1cam), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
L1CAM Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012704HU | Recombinant Human Neural cell adhesion molecule L1 (L1CAM), partial | Yeast |
| CSB-EP012704HU | Recombinant Human Neural cell adhesion molecule L1 (L1CAM), partial | E.coli |
| CSB-BP012704HU CSB-MP012704HU CSB-EP012704HU-B |
Recombinant Human Neural cell adhesion molecule L1 (L1CAM), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP012704HU1 | Recombinant Human Neural cell adhesion molecule L1 (L1CAM), partial (Active) | Mammalian cell |
L1CAM Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP847465TKY CSB-EP847465TKY CSB-BP847465TKY CSB-MP847465TKY CSB-EP847465TKY-B |
Recombinant Takifugu rubripes Neural cell adhesion molecule L1 (l1cam), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
L1CAM ELISA Kit
L1CAM ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09145h | Human Neural cell adhesion molecule ligand 1,NCAM-L1 ELISA Kit | serum, plasma, tissue homogenates | 0.31 ng/mL |
