ITGB7
ITGB7是一種介導(dǎo)細(xì)胞間黏附的重要膜蛋白，其全稱為整合素β7亞基，臨床上常被稱為CD103或淋巴細(xì)胞歸巢受體。該蛋白廣泛分布于腸道、皮膚等黏膜組織的免疫細(xì)胞表面，通過與整合素α4或αE亞基配對(duì)形成異源二聚體，協(xié)助淋巴細(xì)胞定向遷移至炎癥部位。ITGB7功能異常與多種免疫性疾病密切相關(guān)，例如在潰瘍性結(jié)腸炎患者的病變腸道中，整合素β7陽(yáng)性淋巴細(xì)胞異常聚集會(huì)加劇組織損傷。ITGB7在胃腸道T細(xì)胞淋巴瘤中呈現(xiàn)高表達(dá)特征，可能成為鑒別診斷的生物標(biāo)志物。
針對(duì)整合素β7的藥物開發(fā)聚焦于阻斷其介導(dǎo)的病理過程。全球已有多個(gè)單克隆抗體進(jìn)入臨床試驗(yàn)階段，其中Etrolizumab在克羅恩病治療中展現(xiàn)出調(diào)節(jié)腸道炎癥的潛力。部分小分子抑制劑通過干擾蛋白構(gòu)象變化，正在探索對(duì)特應(yīng)性皮炎等疾病的干預(yù)效果。這類藥物需精準(zhǔn)平衡免疫抑制與黏膜屏障保護(hù)的雙重需求，目前仍有待突破性進(jìn)展。
熱銷產(chǎn)品
Recombinant Human Integrin beta-7 (ITGB7), partial (CSB-EP011891HU2)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ITGB7 Antibody (CSB-PA011891ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: ITGB7 antibody at 5.04μg/ml
Lane 1: MCF-7 whole cell lysate
Lane 2: HepG2 whole cell lysate
Lane 3: A549 whole cell lysate
Lane 4: K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 87, 72 kDa
Observed band size: 87 kDa
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA011891ESR1HU at dilution of 1:100
ITGB7 Antibodies
ITGB7 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011891GA01HU | ITGB7 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA939542 | ITGB7 Antibody | Human | ELISA,WB,IHC |
| CSB-PA588701 | ITGB7 Antibody | Human | ELISA,IHC |
| CSB-PA011891ESR1HU | ITGB7 Antibody | Human | ELISA, WB, IHC |
| CSB-PA011891ESR2HU | ITGB7 Antibody | Human | ELISA, IHC |
ITGB7 Proteins
ITGB7 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011891MO1 CSB-EP011891MO1 CSB-BP011891MO1 CSB-MP011891MO1 CSB-EP011891MO1-B |
Recombinant Mouse Integrin beta-7 (Itgb7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011891MO | Recombinant Mouse Integrin beta-7 (Itgb7) | in vitro E.coli expression system |
ITGB7 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011891HU1 CSB-BP011891HU1 CSB-MP011891HU1 CSB-EP011891HU1-B |
Recombinant Human Integrin beta-7 (ITGB7), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011891HU | Recombinant Human Integrin beta-7 (ITGB7) | in vitro E.coli expression system |
| CSB-EP011891HU1 | Recombinant Human Integrin beta-7 (ITGB7), partial | E.coli |
| CSB-EP011891HU2 | Recombinant Human Integrin beta-7 (ITGB7), partial | E.coli |
ITGB7 ELISA Kit
ITGB7 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011891HU | Human Integrin beta-7(ITGB7) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
