IL3
IL3，即白細(xì)胞介素3，別名Interleukin-3、MCGF。IL-3主要由活化的T細(xì)胞和NK細(xì)胞產(chǎn)生，此外，IL-1激活的人內(nèi)皮細(xì)胞、IgE激活的小鼠肥大細(xì)胞和胎盤(pán)細(xì)胞等也能產(chǎn)生IL-3。IL-3的作用機(jī)制主要通過(guò)與其受體結(jié)合并觸發(fā)細(xì)胞內(nèi)信號(hào)傳導(dǎo)過(guò)程來(lái)實(shí)現(xiàn)。IL-3與其受體α鏈（IL-3Rα）結(jié)合后，會(huì)進(jìn)一步與β鏈（IL-3Rβ，CD131）結(jié)合，形成異源二聚體或寡聚體，從而激活受體相關(guān)的Janus激酶（JAK），主要是JAK2。激活的JAK2募集STAT5并介導(dǎo)其磷酸化，磷酸化的STAT5進(jìn)入細(xì)胞核，誘導(dǎo)下游效應(yīng)基因的轉(zhuǎn)錄。此外，IL-3還激活Ras-MAPK和磷酸肌醇3-激酶（PI3K）通路。IL-3是一種重要的造血生長(zhǎng)因子，對(duì)多種細(xì)胞類(lèi)型的發(fā)育起著關(guān)鍵作用，包括粒細(xì)胞、單核細(xì)胞、巨噬細(xì)胞、嗜酸性粒細(xì)胞、嗜堿性粒細(xì)胞和肥大細(xì)胞。IL-3還參與免疫調(diào)節(jié)、炎癥反應(yīng)以及血液系統(tǒng)疾病的治療。
熱銷(xiāo)產(chǎn)品
Recombinant Human Interleukin-3 (IL3) (Active) (CSB-MP011652HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of TF-1 cells is 0.3149 to 1.023 ng/mL.
Recombinant Human Interleukin-3 (IL3) (Active) (CSB-EP011652HUc7)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of TF-1 cells is 5.972-17.16 ng/mL.
IL3 Antibodies
IL3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA011652GA01HU | IL3 Antibody | Human | ELISA,WB |
| CSB-PA06725B0Rb | IL3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA06725A0Rb | IL3 Antibody | Human | ELISA, IHC |
| CSB-PA011652ESR1HU | IL3 Antibody | Human | ELISA, IHC |
| CSB-PA196621 | IL3 Antibody | Human,Mouse | ELISA,WB |
IL3 Proteins
IL3 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011652MOW CSB-EP011652MOW CSB-BP011652MOW CSB-MP011652MOW CSB-EP011652MOW-B |
Recombinant Macaca mulatta (Rhesus macaque) Interleukin-3 (IL3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP001981MOW | Recombinant Rhesus Macaque Interleukin-3 protein (IL3) | E.Coli |
IL3 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011652BO CSB-BP011652BO CSB-MP011652BO CSB-EP011652BO-B |
Recombinant Bovine Interleukin-3 (IL3) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-EP011652MO CSB-BP011652MO CSB-EP011652MO-B |
Recombinant Mouse Interleukin-3 (Il3) | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP003291MO | Recombinant Mouse Interleukin-3 protein (Il3), partial | E.Coli |
IL3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011652RA CSB-EP011652RA CSB-BP011652RA CSB-MP011652RA CSB-EP011652RA-B |
Recombinant Rat Interleukin-3 (Il3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011652HU CSB-BP011652HU CSB-EP011652HU-B |
Recombinant Human Interleukin-3 (IL3) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP011652HU | Recombinant Human Interleukin-3 (IL3) | E.coli |
| CSB-AP001701HU | Recombinant Human Interleukin-3 protein (IL3)(P27S) (Active) | E.Coli |
| CSB-EP011652HUc7 | Recombinant Human Interleukin-3 (IL3) (Active) | E.coli |
| CSB-AP004521HU | Recombinant Human Interleukin-3 (IL3) (Active) | Mammalian cell |
| CSB-AP004531HU | Recombinant Human Interleukin-3 (IL3) (Active) | E.coli |
| CSB-AP005821HU | Recombinant Human Interleukin-3 (IL3), partial (Active) (GMP) | E.Coli |
| CSB-MP011652HU-WD | Recombinant Human Interleukin-3 (IL3) (Active) | Mammalian cell |
| CSB-YP011652HUd7 | Recombinant Human Interleukin-3 (IL3) (Active) | Yeast |
| CSB-MP011652HU | Recombinant Human Interleukin-3 (IL3) (Active) | Mammalian cell |
IL3 Proteins for Saguinus oedipus (Cotton-top tamarin)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011652SWB CSB-EP011652SWB CSB-BP011652SWB CSB-MP011652SWB CSB-EP011652SWB-B |
Recombinant Saguinus oedipus Interleukin-3 (IL3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL3 Proteins for Hylobates lar (Common gibbon)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011652HXW CSB-EP011652HXW CSB-BP011652HXW CSB-MP011652HXW CSB-EP011652HXW-B |
Recombinant Hylobates lar Interleukin-3 (IL3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL3 Proteins for Callithrix jacchus (White-tufted-ear marmoset)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP632965CYL CSB-EP632965CYL CSB-BP632965CYL CSB-MP632965CYL CSB-EP632965CYL-B |
Recombinant Callithrix jacchus Interleukin-3 (IL3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL3 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP637919EQV CSB-EP637919EQV CSB-BP637919EQV CSB-MP637919EQV CSB-EP637919EQV-B |
Recombinant Pan troglodytes Interleukin-3 (IL3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL3 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP860200DO CSB-EP860200DO CSB-BP860200DO CSB-MP860200DO CSB-EP860200DO-B |
Recombinant Dog Interleukin-3 (IL3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL3 ELISA Kit
IL3 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E04631h | Human Interleukin 3,IL-3 ELISA KIT | serum, plasma, tissue homogenates. | 15.6 pg/ml. |
IL3 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E04632m | Mouse Interleukin 3,IL-3 ELISA KIT | serum, plasma, tissue homogenates | 1.95 pg/mL |
IL3 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E07436r | Rat Interleukin 3,IL-3 ELISA KIT | serum, plasma, tissue homogenates | 0.78 pg/mL |
