IL23A
IL23A，即白細(xì)胞介素23α，是位于12號染色體上的一個(gè)基因。該基因編碼的蛋白質(zhì)是白細(xì)胞介素23（IL-23）的一個(gè)亞單位，與IL12B基因編碼的p40亞基結(jié)合，形成具有生物學(xué)活性的IL-23異二聚體。IL-23通過與其特異性受體IL23R結(jié)合，激活下游信號傳導(dǎo)，主要通過JAK-STAT途徑，特別是STAT3和STAT4的激活，促進(jìn)Th17細(xì)胞的分化和增殖，以及細(xì)胞因子如IL-17和IL-22的產(chǎn)生。IL23A在調(diào)節(jié)免疫反應(yīng)中起著關(guān)鍵作用，特別是在促進(jìn)Th17細(xì)胞介導(dǎo)的免疫反應(yīng)中。Th17細(xì)胞與多種炎癥性和自身免疫性疾病的發(fā)生發(fā)展密切相關(guān)，如炎癥性腸病、銀屑病和多發(fā)性硬化癥等。此外，IL-23在腫瘤免疫中也發(fā)揮作用，影響腫瘤的生長和免疫抑制環(huán)境。因此，IL23A是免疫調(diào)節(jié)和相關(guān)疾病治療研究中的一個(gè)重要分子。
熱銷產(chǎn)品
Recombinant Guinea pig Interleukin-23 subunit alpha (IL23A) (CSB-EP757211GU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL23A Recombinant Monoclonal Antibody (CSB-RA251959A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: THP-1 whole cell lysate
All lanes: IL23 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 21 kDa
Observed band size: 21 kDa
Human Interleukin-23 subunit alpha(IL-23A) Elisa kit (CSB-E17339h)
驗(yàn)證數(shù)據(jù)
貨號：CSB-E17339h
規(guī)格：96T/48T
靈敏度：15.6 pg/mL
檢測范圍：62.5 pg/mL-4000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
IL23A Antibodies
IL23A for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA06719A0Rb | IL23A Antibody | Human | ELISA, IHC, IF |
| CSB-PA06719B0Rb | IL23A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA06719C0Rb | IL23A Antibody, FITC conjugated | Human | |
| CSB-PA06719D0Rb | IL23A Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA251959A0HU | IL23A Recombinant Monoclonal Antibody | Human | ELISA, WB |
IL23A Proteins
IL23A Proteins for Equus caballus (Horse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP727376HO CSB-EP727376HO CSB-BP727376HO CSB-MP727376HO CSB-EP727376HO-B |
Recombinant Horse Interleukin-23 subunit alpha (IL23A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL23A Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP757211GU CSB-BP757211GU CSB-MP757211GU CSB-EP757211GU-B |
Recombinant Guinea pig Interleukin-23 subunit alpha (IL23A) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP757211GU | Recombinant Guinea pig Interleukin-23 subunit alpha (IL23A) | E.coli |
IL23A Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP852813RA CSB-EP852813RA CSB-BP852813RA CSB-MP852813RA CSB-EP852813RA-B |
Recombinant Rat Interleukin-23 subunit alpha (Il23a) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL23A Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP863641MO CSB-BP863641MO CSB-EP863641MO-B |
Recombinant Mouse Interleukin-23 subunit alpha (Il23a) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP863641MO | Recombinant Mouse Interleukin-23 subunit alpha (Il23a) | E.coli |
| CSB-CF863641MOd7 | Recombinant Mouse Interleukin-23 subunit alpha (Il23a) | in vitro E.coli expression system |
IL23A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP868278HU CSB-EP868278HU CSB-BP868278HU CSB-EP868278HU-B |
Recombinant Human Interleukin-23 subunit alpha (IL23A) | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP004661HU | Recombinant Human IL23A & IL12B Heterodimer Protein (Active) | Mammalian cell |
IL23A Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP873568PI CSB-BP873568PI CSB-EP873568PI-B |
Recombinant Pig Interleukin-23 subunit alpha (IL23A) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF873568PI | Recombinant Pig Interleukin-23 subunit alpha (IL23A) | in vitro E.coli expression system |
IL23A ELISA Kit
IL23A ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17339h | Human Interleukin-23 subunit alpha(IL-23A) Elisa kit | serum, plasma, cell culture supernates, tissue homogenates, cell lysates | 15.6 pg/mL |
IL23A ELISA Kit for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011638PI | Pig Interleukin-23 subunit alpha(IL23A) ELISA kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
