IL1R1
IL1R1，即白細(xì)胞介素-1受體1，別名CD121a、IL1R、IL1RA、IL1RT1。它是一種細(xì)胞膜上的受體蛋白，屬于白細(xì)胞介素1（IL-1）信號(hào)通路的關(guān)鍵組成部分。IL1R1來(lái)源于多種細(xì)胞類(lèi)型，包括特定的內(nèi)皮細(xì)胞、心室細(xì)胞、星形膠質(zhì)細(xì)胞和神經(jīng)元。
IL1R1通過(guò)與IL-1α、IL-1β、IL-1Ra和IL-38結(jié)合，激活包括NF-κB和MAPK在內(nèi)的信號(hào)通路，從而調(diào)節(jié)多種促炎細(xì)胞因子的轉(zhuǎn)錄并介導(dǎo)免疫和炎癥反應(yīng)。IL1R1在免疫調(diào)節(jié)、炎癥過(guò)程中起著重要作用，它在許多炎癥性和免疫性疾病中發(fā)揮著關(guān)鍵的調(diào)控作用，如風(fēng)濕性關(guān)節(jié)炎、炎癥性腸病、類(lèi)風(fēng)濕性關(guān)節(jié)炎等，是治療這些疾病的一個(gè)潛在靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
Recombinant Human Interleukin-1 receptor type 1 (IL1R1) (CSB-CF011621HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL1R1 Recombinant Monoclonal Antibody (CSB-RA011621MA1HU)
驗(yàn)證數(shù)據(jù)
Overlay Peak curve showing NIH/3T3 cells surface stained with CSB-RA011621MA1HU (red line) at 1:50. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
IL1R1 Antibodies
IL1R1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA011621ESR1HU | IL1R1 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA011621ESR2HU | IL1R1 Antibody | Human | ELISA, IHC |
| CSB-PA005251 | IL1R1 Antibody | Human | WB, ELISA |
| CSB-PA009540 | Phospho-IL1R1 (Y496) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA727952 | IL1R1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA072110 | IL1R1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA011621EA01HU | IL1R1 Antibody | Human | ELISA, WB, IF |
| CSB-PA011621EB01HU | IL1R1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA011621EC01HU | IL1R1 Antibody, FITC conjugated | Human | |
| CSB-PA011621ED01HU | IL1R1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA011621MA1HU | IL1R1 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, FC |
IL1R1 Proteins
IL1R1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011621MO1 CSB-EP011621MO1 CSB-BP011621MO1 CSB-EP011621MO1-B |
Recombinant Mouse Interleukin-1 receptor type 1 (Il1r1), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF011621MO | Recombinant Mouse Interleukin-1 receptor type 1 (Il1r1) | in vitro E.coli expression system |
IL1R1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011621HU CSB-EP011621HU CSB-BP011621HU CSB-EP011621HU-B |
Recombinant Human Interleukin-1 receptor type 1 (IL1R1), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF011621HU | Recombinant Human Interleukin-1 receptor type 1 (IL1R1) | in vitro E.coli expression system |
| CSB-MP011621HU | Recombinant Human Interleukin-1 receptor type 1 (IL1R1)-VLPs | Mammalian cell |
IL1R1 ELISA Kit
IL1R1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E04611h | Human soluble interleukin-1 receptor Ⅰ,IL-1sRⅠ ELISA kit | serum, plasma,tissue homogenates | 0.039 ng/ml |
