HSP90B1
HSP90B1，全稱為熱休克蛋白90kDa beta亞家族成員1，在人體內廣泛存在，也被稱為endoplasmin、gp96、GRP94或ERp99。它是一種分子伴侶蛋白，主要位于內質網中，在蛋白質的折疊、轉運和組裝過程中發揮著關鍵作用。HSP90B1能夠幫助蛋白質正確折疊，并保護它們免受損傷，從而維持細胞的正常功能。此外，HSP90B1還參與免疫調節，并被認為是腫瘤免疫治療的重要靶點。
HSP90B1與多種疾病密切相關，包括癌癥、自身免疫性疾病和神經退行性疾病等。在癌癥治療中，HSP90B1已被證明是多種癌癥免疫治療藥物的靶點。例如，vitespen（HSP90B1的腫瘤衍生形式）已被用于治療黑色素瘤。此外，研究人員正在開發針對HSP90B1的抑制劑，以治療癌癥和其他疾病。
在藥物研發方面，HSP90B1已成為一個重要的靶點。由于HSP90B1在維持細胞內蛋白質穩態方面發揮著關鍵作用，因此抑制HSP90B1可能有助于治療多種疾病。目前，已有多種針對HSP90B1的抑制劑進入臨床試驗階段，用于治療癌癥、自身免疫性疾病和神經退行性疾病等。
熱銷產品
Recombinant Human Endoplasmin (HSP90B1), partial (CSB-EP010814HU1)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP108894h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HSP90B1.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP108894h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HSP90B1.
HSP90B1 Antibody (CSB-PA002347)
驗證數據
Western Blot analysis of HeLa cells using Endoplasmin Polyclonal Antibody
Western Blot analysis of K562 cells using Endoplasmin Polyclonal Antibody
Human Heat Shock Protein glycoprotein 96,HSP gp96 ELISA Kit (CSB-E08551h)
驗證數據
貨號：CSB-E08551h
規格：96T/48T
靈敏度：0.156 ng/mL
檢測范圍：0.625 ng/mL-40 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
HSP90B1 Antibodies
HSP90B1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA010814GA01HU | HSP90B1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA10887A0Rb | HSP90B1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA10887C0Rb | HSP90B1 Antibody, FITC conjugated | Human | |
| CSB-PA002347 | HSP90B1 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA179036 | HSP90B1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA088395 | HSP90B1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
HSP90B1 Proteins
HSP90B1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010814HU CSB-EP010814HU CSB-BP010814HU CSB-MP010814HU CSB-EP010814HU-B |
Recombinant Human Endoplasmin (HSP90B1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP010814HU1 | Recombinant Human Endoplasmin (HSP90B1), partial | E.coli |
HSP90B1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010814DO CSB-EP010814DO CSB-BP010814DO CSB-MP010814DO CSB-EP010814DO-B |
Recombinant Dog Endoplasmin (HSP90B1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010814CH CSB-EP010814CH CSB-BP010814CH CSB-MP010814CH CSB-EP010814CH-B |
Recombinant Chicken Endoplasmin (HSP90B1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010814MO CSB-EP010814MO CSB-BP010814MO CSB-MP010814MO CSB-EP010814MO-B |
Recombinant Mouse Endoplasmin (Hsp90b1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Oryctolagus cuniculus (Rabbit)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010814RB CSB-EP010814RB CSB-BP010814RB CSB-MP010814RB CSB-EP010814RB-B |
Recombinant Rabbit Endoplasmin (HSP90B1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Mesocricetus auratus (Golden hamster)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010814MRG CSB-EP010814MRG CSB-BP010814MRG CSB-MP010814MRG CSB-EP010814MRG-B |
Recombinant Mesocricetus auratus Endoplasmin (HSP90B1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP641820PI CSB-EP641820PI CSB-BP641820PI CSB-MP641820PI CSB-EP641820PI-B |
Recombinant Pig Endoplasmin (HSP90B1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP703101MOV CSB-EP703101MOV CSB-BP703101MOV CSB-MP703101MOV CSB-EP703101MOV-B |
Recombinant Macaca fascicularis Endoplasmin (HSP90B1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP714884RA CSB-EP714884RA CSB-BP714884RA CSB-MP714884RA CSB-EP714884RA-B |
Recombinant Rat Endoplasmin (Hsp90b1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Pongo abelii (Sumatran orangutan)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP716064PYX CSB-EP716064PYX CSB-BP716064PYX CSB-MP716064PYX CSB-EP716064PYX-B |
Recombinant Pongo abelii Endoplasmin (HSP90B1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP839213BO CSB-EP839213BO CSB-BP839213BO CSB-MP839213BO CSB-EP839213BO-B |
Recombinant Bovine Endoplasmin (HSP90B1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 ELISA Kit
HSP90B1 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08551h | Human Heat Shock Protein glycoprotein 96,HSP gp96 ELISA Kit | serum, plasma, tissue homogenates | 0.156 ng/mL |
