GUCY2C
GUCY2C，即鳥苷酸環化酶2C，別名GC-C、STaR、DIAR6、GUC2C、MECIL、MUCIL等。這是一種在人體中由GUCY2C基因編碼的跨膜蛋白，屬于受體鳥苷酸環化酶家族。GUCY2C主要在腸上皮細胞中表達，其蛋白結構由細胞外配體結合結構域、跨膜結構域、細胞質結構域、催化區和羧基末端區域組成。GUCY2C的作用機制是通過其配體，如鳥苷素、尿鳥苷素以及熱穩定性腸毒素STa的結合，激活GUCY2C，進而催化細胞內第二信使環磷酸鳥苷（cGMP）的產生，這一過程在調節體內平衡、維持腸道屏障功能和發揮抗炎作用中發揮重要作用。GUCY2C的異常表達與多種疾病相關，包括家族性腹瀉、胎糞性腸梗阻、結直腸癌等。
熱銷產品
Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) (CSB-MP010053HUd9)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized human GUCY2C at 5 μg/ml can bind Anti-GUCY2C recombinant antibody (CSB-RA010053A2HU), the EC50 is 3.049-4.660 ng/mL.
GUCY2C Recombinant Monoclonal Antibody (CSB-RA010053A3HU)
驗證數據
The Binding Activity of Human GUCY2C with Anti-GUCY2C recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GUCY2C (CSB-MP010053HU) at 5 μg/mL can bind Anti-GUCY2C recombinant antibody, the EC50 is 5.630-9.996 ng/mL.
T84 cells were stained with Human IgG (green line) and anti-GUCY2C antibody (red line) (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
Untransfected CT26 cells surface (green line) and transfected Human GUCY2C CT26 stable cells surface (red line) were stained with anti-GUCY2C antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
GUCY2C Antibodies
GUCY2C for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA010053LA01HU | GUCY2C Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA010053LB01HU | GUCY2C Antibody, HRP conjugated | Human | ELISA |
| CSB-PA010053LC01HU | GUCY2C Antibody, FITC conjugated | Human | |
| CSB-PA010053LD01HU | GUCY2C Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA010053A2HU | GUCY2C Recombinant Monoclonal Antibody | Human | ELISA, FC |
| CSB-RA010053A3HU | GUCY2C Recombinant Monoclonal Antibody | Human | ELISA, FC |
GUCY2C Proteins
GUCY2C Proteins for Cavia porcellus (Guinea pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010053GU CSB-EP010053GU CSB-BP010053GU CSB-MP010053GU CSB-EP010053GU-B |
Recombinant Guinea pig Heat-stable enterotoxin receptor (GUCY2C), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GUCY2C Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial | Yeast |
| CSB-EP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial | E.coli |
| CSB-BP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial | Baculovirus |
| CSB-MP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial | Mammalian cell |
GUCY2C Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010053PI CSB-EP010053PI CSB-BP010053PI CSB-MP010053PI CSB-EP010053PI-B |
Recombinant Pig Heat-stable enterotoxin receptor (GUCY2C), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GUCY2C Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010053HU CSB-EP010053HU CSB-EP010053HU-B |
Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-BP010053HU | Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial | Baculovirus |
| CSB-MP010053HU | Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) | Mammalian cell |
| CSB-MP010053HUd9 | Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) | Mammalian cell |
GUCY2C Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP664972MO CSB-EP664972MO CSB-EP664972MO-B |
Recombinant Mouse Heat-stable enterotoxin receptor (Gucy2c), partial | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-BP664972MO | Recombinant Mouse Heat-stable enterotoxin receptor (Gucy2c), partial | Baculovirus |
| CSB-MP664972MO | Recombinant Mouse Heat-stable enterotoxin receptor (Gucy2c), partial | Mammalian cell |
