FZD7
FZD7（Frizzled-7）是卷曲蛋白家族成員之一，別名Fz-7或hFz7。這類跨膜受體蛋白通過與Wnt蛋白配體結(jié)合，調(diào)控胚胎發(fā)育、組織穩(wěn)態(tài)等重要生理過程。FZD7激活后主要介導(dǎo)Wnt/β-catenin經(jīng)典通路，促進(jìn)β-catenin入核啟動靶基因轉(zhuǎn)錄，同時(shí)也能通過非經(jīng)典通路影響細(xì)胞極性和遷移。FZD7在多種惡性腫瘤中異常高表達(dá)，包括結(jié)直腸癌、三陰性乳腺癌和肝細(xì)胞癌，其過表達(dá)與腫瘤干細(xì)胞特性增強(qiáng)、化療耐藥及轉(zhuǎn)移密切相關(guān)。目前針對FZD7的靶向藥物開發(fā)尚處早期階段，已有研究報(bào)道通過單克隆抗體阻斷其與Wnt配體結(jié)合，在動物模型中顯示出抑制腫瘤生長的效果。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
Western Blot analysis of HELA cells using Frizzled-7 Polyclonal Antibody
Western Blot analysis of HELA cells using Frizzled-7 Polyclonal Antibody
FZD7 Antibodies
FZD7 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009110GA01HU | FZD7 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA002581 | FZD7 Antibody | Human,Mouse | WB, IF, ELISA |
| CSB-PA009110LA01HU | FZD7 Antibody | Human | ELISA, WB, IHC |
| CSB-PA009110LB01HU | FZD7 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA009110LC01HU | FZD7 Antibody, FITC conjugated | Human |
FZD7 Proteins
FZD7 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009110HU1 CSB-EP009110HU1 CSB-BP009110HU1 CSB-MP009110HU1 CSB-EP009110HU1-B |
Recombinant Human Frizzled-7 (FZD7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009110HU | Recombinant Human Frizzled-7 (FZD7) | in vitro E.coli expression system |
FZD7 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009110CH1 CSB-EP009110CH1 CSB-BP009110CH1 CSB-MP009110CH1 CSB-EP009110CH1-B |
Recombinant Chicken Frizzled-7 (FZD7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009110CH | Recombinant Chicken Frizzled-7 (FZD7) | in vitro E.coli expression system |
FZD7 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP704724XBF1 CSB-EP704724XBF1 CSB-BP704724XBF1 CSB-MP704724XBF1 CSB-EP704724XBF1-B |
Recombinant Xenopus tropicalis Frizzled-7 (fzd7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF704724XBF | Recombinant Xenopus tropicalis Frizzled-7 (fzd7) | in vitro E.coli expression system |
FZD7 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP730721MO1 CSB-EP730721MO1 CSB-BP730721MO1 CSB-MP730721MO1 CSB-EP730721MO1-B |
Recombinant Mouse Frizzled-7 (Fzd7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF730721MO | Recombinant Mouse Frizzled-7 (Fzd7) | in vitro E.coli expression system |
