FLT3
FLT3，即FMS樣酪氨酸激酶3，別名CD135。它是一種III型受體酪氨酸激酶（RTK），在造血干細(xì)胞、前體B細(xì)胞等的增殖、分化以及存活中具有重要作用。FLT3基因突變是急性髓系白血病（AML）患者中最常見的基因改變之一，也是預(yù)后不良的重要因素。這些突變導(dǎo)致FLT3受體在不依賴FLT3配體（FL）的情況下，持續(xù)自身磷酸化，異常激活下游的信號(hào)通路，如PI3K/AKT、RAS/MAPK/ERK和STAT5等，從而促進(jìn)細(xì)胞增殖和抑制凋亡。FLT3對(duì)于維持正常的造血功能至關(guān)重要。然而，當(dāng)FLT3發(fā)生突變時(shí)，它可能導(dǎo)致白血病的發(fā)生。FLT3突變的AML患者通常具有較高的外周血白細(xì)胞計(jì)數(shù)、較差的臨床預(yù)后，并且容易復(fù)發(fā)。FLT3抑制劑的開發(fā)為AML患者提供了新的治療選擇，這些抑制劑通過競(jìng)爭(zhēng)性抑制FLT3受體中的ATP結(jié)合位點(diǎn)，導(dǎo)致細(xì)胞周期停滯和分化，從而抑制白血病細(xì)胞的增殖。
熱銷產(chǎn)品
Recombinant Human Receptor-type tyrosine-protein kinase FLT3 (FLT3), partial (CSB-BP008733HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA930678(FLT3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA930678(FLT3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
Human FMS-like tyrosine kinase 3,Flt3 ELISA Kit (CSB-E04556h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E04556h
規(guī)格：96T/48T
靈敏度：15.6 pg/mL
檢測(cè)范圍：62.5 pg/mL-4000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
FLT3 Antibodies
FLT3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA008733GA01HU | FLT3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA546306 | FLT3 (Ab-591) Antibody | Human | ELISA,WB,IF |
| CSB-PA254158 | Phospho-FLT3 (Tyr842) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA006265 | FLT3 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008339 | Phospho-FLT3 (Y599) Antibody | Human,Mouse,Monkey | WB, ELISA |
| CSB-PA008340 | Phospho-FLT3 (Y842) Antibody | Human,Mouse | WB, ELISA |
| CSB-PA008341 | Phospho-FLT3 (Y969) Antibody | Human | WB, IHC, ELISA |
| CSB-PA008343 | FLT3 Antibody | Human,Mouse | WB, ELISA |
| CSB-PA930678 | FLT3 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA922469 | FLT3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA008733LA01HU | FLT3 Antibody | Human | ELISA, WB |
| CSB-PA008733LB01HU | FLT3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008733LC01HU | FLT3 Antibody, FITC conjugated | Human | |
| CSB-PA008733LD01HU | FLT3 Antibody, Biotin conjugated | Human | ELISA |
FLT3 Proteins
FLT3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008733HU CSB-EP008733HU CSB-BP008733HU CSB-MP008733HU CSB-EP008733HU-B |
Recombinant Human Receptor-type tyrosine-protein kinase FLT3 (FLT3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP008733HU1 | Recombinant Human Receptor-type tyrosine-protein kinase FLT3 (FLT3), partial | Baculovirus |
| CSB-BP008733HU1b0 | Recombinant Human Receptor-type tyrosine-protein kinase FLT3 (FLT3), partial | Baculovirus |
| CSB-BP008733HU1a0 | Recombinant Human Receptor-type tyrosine-protein kinase FLT3 (FLT3), partial | Baculovirus |
| CSB-EP008733HU1 | Recombinant Human Receptor-type tyrosine-protein kinase FLT3 (FLT3), partial | E.coli |
FLT3 ELISA Kit
FLT3 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04556h | Human FMS-like tyrosine kinase 3,Flt3 ELISA Kit | serum, plasma, tissue homogenates | 15.6 pg/mL |
