EPHA2

EphA2，全稱為Erythropoietin-producing hepatocellular A2，是一種關鍵的受體酪氨酸激酶。它參與細胞信號轉導、細胞間相互作用以及組織發(fā)育等多種生物學過程。EphA2蛋白在胚胎發(fā)育中發(fā)揮重要作用，如調節(jié)血管生成、后腦發(fā)育和乳腺形態(tài)發(fā)生等。此外，它還與丙型肝炎病毒的感染機制相關，作為病毒受體促進病毒進入細胞。
近年來，EphA2蛋白在癌癥發(fā)生和發(fā)展中的作用逐漸被揭示。研究發(fā)現(xiàn)，EphA2蛋白在癌癥中具有雙重角色：一方面，它可以抑制癌癥的生長和擴散；另一方面，經過某些腫瘤相關蛋白修飾后，EphA2可能促進癌癥的發(fā)生。這種復雜性使得EphA2成為癌癥治療研究的重要靶點。目前，針對EphA2的靶向治療藥物正在研發(fā)中，有望為癌癥患者提供新的治療策略。

熱銷產品

Recombinant Human Ephrin type-A receptor 2 (EPHA2F), partial (Active) (CSB-MP007722HUd7)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human EPHA2 at 2 μg/ml can bind Anti-EPHA2 recombinant antibody (CSB-RA007722MA1HU). The EC₅₀ is 36.24-50.53 ng/mL.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human EPHA2 at 2 μg/ml can bind Human EFNA1 (CSB-MP007460HU). The EC₅₀ is 5.859-7.758 ng/mL.

The purity of EPHA2F was greater than 95% as determined by SEC-HPLC

EPHA2 Antibody (CSB-PA007722LA01HU)

驗證數(shù)據(jù)

IHC image of CSB-PA007722LA01HU diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of A549 cells with CSB-PA007722LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Ephrin type-A receptor 2(EPHA2) ELISA kit (CSB-EL007722HU)

驗證數(shù)據(jù)

貨號：CSB-EL007722HU

規(guī)格：96T/48T

靈敏度：0.039 ng/mL

檢測范圍：0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

EPHA2 Antibody

EPHA2 Protein

EPHA2 ELISA Kit

EPHA2 Antibodies

EPHA2 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA007722GA01HU	EPHA2 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA282887	EPHA2 Antibody	Human	ELISA,WB
CSB-PA000520	Phospho-EPHA2 (Y588) Antibody	Human,Mouse	WB, ELISA
CSB-PA007983	EPHA2 Antibody	Human,Mouse	WB, ELISA
CSB-PA179150	EPHA2 Antibody	Human,Mouse	ELISA,IHC
CSB-PA007722LA01HU	EPHA2 Antibody	Human	ELISA, IHC, IF
CSB-PA007722LB01HU	EPHA2 Antibody, HRP conjugated	Human	ELISA
CSB-PA007722LC01HU	EPHA2 Antibody, FITC conjugated	Human
CSB-PA007722LD01HU	EPHA2 Antibody, Biotin conjugated	Human	ELISA

EPHA2 Proteins

EPHA2 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP007722HU CSB-EP007722HU CSB-BP007722HU CSB-EP007722HU-B	Recombinant Human Ephrin type-A receptor 2 (EPHA2), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP007722HU	Recombinant Human Ephrin type-A receptor 2 (EPHA2), partial	Mammalian cell
CSB-EP007722HU1	Recombinant Human Ephrin type-A receptor 2 (EPHA2), partial	E.coli
CSB-AP005591HU	Recombinant Human Ephrin type-A receptor 2 (EPHA2), partial (Active)	Mammalian cell
CSB-MP007722HUd7	Recombinant Human Ephrin type-A receptor 2 (EPHA2F), partial (Active)	Mammalian cell

EPHA2 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

產品貨號	產品名稱	來源
CSB-YP628848MOV CSB-EP628848MOV CSB-BP628848MOV CSB-MP628848MOV CSB-EP628848MOV-B	Recombinant Macaca fascicularis Ephrin type-A receptor 2 (EPHA2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli