EGLN2
Egl nine homolog 2 is a protein in humans that is encoded by EGLN2 gene. Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle.
EGLN2 Antibodies
EGLN2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA007482GA01HU | EGLN2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA007482EA01HU | EGLN2 Antibody | Human | ELISA, IHC, IF |
EGLN2 Proteins
EGLN2 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP738149RA CSB-EP738149RA CSB-BP738149RA CSB-MP738149RA CSB-EP738149RA-B |
Recombinant Rat Egl nine homolog 2 (Egln2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EGLN2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP849679MO CSB-EP849679MO CSB-BP849679MO CSB-MP849679MO CSB-EP849679MO-B |
Recombinant Mouse Egl nine homolog 2 (Egln2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EGLN2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-EP007482HU | Recombinant Human Egl nine homolog 2 (EGLN2), partial | E.coli |
| CSB-EP007482HUa2 | Recombinant Human Egl nine homolog 2 (EGLN2), Partial | E.coli |
