DYRK4
DYRK4（雙特異性酪氨酸磷酸化調(diào)節(jié)激酶4）屬于DYRK激酶家族，在細(xì)胞周期調(diào)控和應(yīng)激響應(yīng)中具有關(guān)鍵作用。該蛋白通過(guò)磷酸化下游靶點(diǎn)調(diào)控細(xì)胞存活與分化，尤其在癌細(xì)胞中常通過(guò)抑制凋亡通路維持腫瘤細(xì)胞增殖。DYRK4異常表達(dá)與肝癌、胰腺癌等實(shí)體瘤進(jìn)展相關(guān)，其過(guò)度激活可能加速腫瘤細(xì)胞對(duì)化療藥物的耐受性。在神經(jīng)系統(tǒng)中，DYRK4與阿爾茨海默病相關(guān)的tau蛋白異常磷酸化存在潛在關(guān)聯(lián)，可能參與神經(jīng)纖維纏結(jié)的形成。針對(duì)DYRK4的藥物開(kāi)發(fā)，部分研究機(jī)構(gòu)已篩選出選擇性激酶抑制劑，如INDY和化合物5-碘雷帕霉素衍生物，這些候選藥物在體外實(shí)驗(yàn)中顯示出抑制腫瘤生長(zhǎng)的潛力。
熱銷(xiāo)產(chǎn)品
DYRK4 Antibody (CSB-PA882080LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA882080LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA882080LA01HU at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA882080LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
DYRK4 Antibodies
DYRK4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA007313GA01HU | DYRK4 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA070148 | DYRK4 Antibody | Human | WB, ELISA |
| CSB-PA882080LA01HU | DYRK4 Antibody | Human | ELISA, IHC, IF |
| CSB-PA882080LD01HU | DYRK4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA882080LC01HU | DYRK4 Antibody, FITC conjugated | Human |
DYRK4 Proteins
DYRK4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP882080HU CSB-EP882080HU CSB-BP882080HU CSB-MP882080HU CSB-EP882080HU-B |
Recombinant Human Dual specificity tyrosine-phosphorylation-regulated kinase 4 (DYRK4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
