DOK3
DOK3，全稱為Docking protein 3，別稱DOKL、Dok-like protein、Downstream of tyrosine kinase 3、FLJ22570、FLJ39939、p62(dok)-like protein或p62Dok-like protein。DOK3蛋白主要表達(dá)于骨髓、脾臟、粒細(xì)胞、肺、淋巴結(jié)和骨 marrow等組織中。它在細(xì)胞信號轉(zhuǎn)導(dǎo)中發(fā)揮重要作用，參與調(diào)控多種細(xì)胞過程，如細(xì)胞增殖、分化和凋亡。DOK3蛋白通過與其他蛋白質(zhì)相互作用，形成信號復(fù)合物，從而影響細(xì)胞行為。研究表明，DOK3蛋白可能與PRDX1蛋白相互作用，形成復(fù)合物，參與調(diào)控類風(fēng)濕性關(guān)節(jié)炎的發(fā)生發(fā)展。此外，DOK3蛋白還可能與ABL1蛋白相互作用，調(diào)節(jié)ABL1的功能。目前，針對DOK3蛋白的藥物研發(fā)尚處于早期階段，但已有研究表明，靶向DOK3蛋白的藥物可能對類風(fēng)濕性關(guān)節(jié)炎和急性髓系白血病等疾病具有治療潛力。
熱銷產(chǎn)品
DOK3 Antibody (CSB-PA007019LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: Mouse heart tissue, Human placenta tissue
All lanes: DOK3 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 54, 24, 36, 25 kDa
Observed band size: 54 kDa
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA007019LA01HU at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA007019LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
DOK3 Antibodies
DOK3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA007109GA01HU | DOK3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA002182 | DOK3 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA338014 | DOK3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA007019LA01HU | DOK3 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA007019LB01HU | DOK3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA007019LC01HU | DOK3 Antibody, FITC conjugated | Human | |
| CSB-PA007019LD01HU | DOK3 Antibody, Biotin conjugated | Human | ELISA |
DOK3 Proteins
DOK3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007109HU CSB-EP007109HU CSB-BP007109HU CSB-MP007109HU CSB-EP007109HU-B |
Recombinant Human Docking protein 3 (DOK3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
