DIS3
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.
DIS3 Antibodies
DIS3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006911GA01HU | DIS3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA897532LA01HU | DIS3 Antibody | Human | ELISA, IHC |
DIS3 Proteins
DIS3 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP334234SXV CSB-EP334234SXV CSB-BP334234SXV CSB-MP334234SXV CSB-EP334234SXV-B |
Recombinant Schizosaccharomyces pombe Exosome complex exonuclease dis3 (dis3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DIS3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP880423MO CSB-EP880423MO CSB-BP880423MO CSB-MP880423MO CSB-EP880423MO-B |
Recombinant Mouse Exosome complex exonuclease RRP44 (Dis3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DIS3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP897532HU CSB-EP897532HU CSB-BP897532HU CSB-MP897532HU CSB-EP897532HU-B |
Recombinant Human Exosome complex exonuclease RRP44 (DIS3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
