DDX21
DDX21 is a protein in humans that is encoded by DDX21 gene. RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II (promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes. In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes. Functions as cofactor for JUN-activated transcription required for phosphorylation of JUN at 'Ser-77'. Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase).
DDX21 Antibodies
DDX21 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006612GA01HU | DDX21 Antibody | Human | ELISA,WB,IHC,IF |
DDX21 Proteins
DDX21 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP662877RA CSB-EP662877RA CSB-BP662877RA CSB-MP662877RA CSB-EP662877RA-B |
Recombinant Rat Nucleolar RNA helicase 2 (Ddx21) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDX21 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP881308MO CSB-EP881308MO CSB-BP881308MO CSB-MP881308MO CSB-EP881308MO-B |
Recombinant Mouse Nucleolar RNA helicase 2 (Ddx21), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDX21 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP882081HU CSB-BP882081HU CSB-MP882081HU CSB-EP882081HU-B |
Recombinant Human Nucleolar RNA helicase 2 (DDX21) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP882081HU | Recombinant Human Nucleolar RNA helicase 2 (DDX21) | E.coli |
