DDIT3
DDIT3，即DNA損傷誘導(dǎo)轉(zhuǎn)錄本3，別名CHOP、GADD153，是一種轉(zhuǎn)錄因子，對(duì)細(xì)胞應(yīng)激反應(yīng)尤其是內(nèi)質(zhì)網(wǎng)應(yīng)激具有關(guān)鍵調(diào)控作用。它通過(guò)與ATF4相互作用，促進(jìn)自噬相關(guān)基因表達(dá)，并通過(guò)抑制mTOR信號(hào)通路激活細(xì)胞自噬。DDIT3還參與凋亡過(guò)程，通過(guò)調(diào)節(jié)Bcl-2家族和C/EBPδ誘導(dǎo)線粒體相關(guān)凋亡。DDIT3在腫瘤細(xì)胞自噬與凋亡調(diào)控中扮演重要角色，其異常表達(dá)可能增加腫瘤細(xì)胞對(duì)治療的敏感性，是腫瘤治療的潛在靶點(diǎn)。在谷氨酰胺饑餓條件下，DDIT3通過(guò)雙重機(jī)制平衡糖酵解和線粒體氧化磷酸化，減少活性氧產(chǎn)生，幫助腫瘤細(xì)胞適應(yīng)代謝壓力，顯示其在腫瘤細(xì)胞代謝調(diào)控中的生物學(xué)意義。
熱銷產(chǎn)品
DDIT3 Recombinant Monoclonal Antibody (CSB-RA918842A0HU)
驗(yàn)證數(shù)據(jù)
Overlay Peak curve showing Hela cells stained with CSB-RA918842A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
DDIT3 Antibodies
DDIT3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006589GA01HU | DDIT3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA071811 | DDIT3 Antibody | Human,Mouse,Rat | ELISA, WB, IHC, IF |
| CSB-PA799326 | Phospho-DDIT3 (Ser30) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA001639 | DDIT3 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA001640 | DDIT3 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA007699 | Phospho-DDIT3 (S30) Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA006589LA01HU | DDIT3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA006589LB01HU | DDIT3 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA918842A0HU | DDIT3 Recombinant Monoclonal Antibody | Human | ELISA, FC |
DDIT3 Proteins
DDIT3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006589HU CSB-EP006589HU CSB-BP006589HU CSB-MP006589HU CSB-EP006589HU-B |
Recombinant Human DNA damage-inducible transcript 3 protein (DDIT3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDIT3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006589MO CSB-EP006589MO CSB-BP006589MO CSB-MP006589MO CSB-EP006589MO-B |
Recombinant Mouse DNA damage-inducible transcript 3 protein (Ddit3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDIT3 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006589DXU CSB-EP006589DXU CSB-BP006589DXU CSB-MP006589DXU CSB-EP006589DXU-B |
Recombinant Cricetulus griseus DNA damage-inducible transcript 3 protein (DDIT3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDIT3 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP606584BO CSB-EP606584BO CSB-BP606584BO CSB-MP606584BO CSB-EP606584BO-B |
Recombinant Bovine DNA damage-inducible transcript 3 protein (DDIT3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDIT3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP737096RA CSB-EP737096RA CSB-BP737096RA CSB-MP737096RA CSB-EP737096RA-B |
Recombinant Rat DNA damage-inducible transcript 3 protein (Ddit3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
